(1,3)-β葡聚糖检测对真菌感染的诊断性能评价

Data mining of plasma(1,3)-β-glucan detection for the diagnosis of fungous infection

目的结合临床微生物学检验和临床信息,对血浆(1,3)-β葡聚糖检测进行数据挖掘,寻找其对侵袭性真菌感染的诊断价值。方法依托实验信息系统(LIS)与医院信息系统(HIS)的数据信息平台,回顾分析泸州医学院附属医院2010年6月1日至2011年7月4日所有(1,3)-β葡聚糖检验病例,同时搜索其深部痰培养或痰涂片查真菌检查结果,采用SPSS统计软件构建评估(1,3)-β葡聚糖检验与侵袭性真菌感染的ROC数据集。结果纳入研究的567例(1,3)-β葡聚糖检验病例中,155例深部痰培养或痰涂片查真菌结果阳性,412例结果阴性。将(1,3)-β葡聚糖检测值和深部痰培养或痰涂片查真菌结果输入SPSS软件,其AUC达到0.6612(P<0.05)。结论血浆(1,3)-β葡聚糖检测较传统的真菌培养法简便、快速、阳性率高,可用于侵袭性真菌感染的早期快速诊断。

Objective To perform data mining,combined with clinical microbiology and clinical information,to explore the diagnostic value of plasma（1,3）-β-glucan in the detection of invasive fungal infection.Methods Based on the data information platform of laboratory information system（LIS） and hospital information system（HIS）,（1,3）-β-glucan examination data of this hospital between June 1st,2010 and July 4th,2011 were retrospectively analyzed,and deep sputum fungal culture or sputum smear test results were collected.SPSS statistical software was used to build ROC database to evaluate（1,3）-β-glucan test and invasive fungal infection.Results 567 cases of（1,3）-β-glucan test were included in this study,including 155 positive cases for deep sputum fungal culture or sputum smear detection and 412 negative cases.（1,3）-β-glucan detection values and deep sputum fungal culture or sputum smear results were inputted and analyzed by SPSS software,and the AUC was 0.661（P0.000 1）.Conclusion The detection of plasma（1,3）-β-glucan might be faster and with higher positive rate than fungal culture,and could be used for the early diagnosis of invasive fungal infection.