儿童血清胱抑素C参考区间的建立

Construction of children serum cyctatin C reference interval

目的建立本实验室儿童血清胱抑素C的参考区间。方法通过比较儿童与成人的血清胱抑素C水平,比较其参考区间的差异,对儿童血清胱抑素C进行对数转换后进行正态性统计分析,从而建立其参考区间。结果血清胱抑素C经对数转换后呈近正态分布,1～16岁儿童血清胱抑素C水平:男性(0.86±0.225)mg/L、女性(0.81±0.218)mg/L与青年组的血清胱抑素C水平:男性(0.87±0.192)mg/L、女性(0.83±0.202)mg/L之间的差异无统计学意义(P>0.5),但与中年组的血清胱抑素C水平:男性(0.93±0.200)mg/L、女性(0.85±0.199)mg/L和老年组的血清胱抑素C水平;男性(1.07±0.216)mg/L、女性(1.00±0.219)mg/L的差异有统计学意义(P<0.01),在儿童组中,男、女组之间差异有统计学意义(P<0.01)。结论本实验儿童血清胱抑素C水平的参考区间:0.42～1.30mg/L(男)、0.38～1.24mg/L(女)。

Objective To construct the reference range of serum cystatin C in children.Methods The reference range of chil- dren was constructed by compared with that of adults and statistical analysis after logarithmic transformation.Results Serum cystatin C levels were close to the normal distribution after logarithmic transformation.In children group , the level of serum cystatin C was （ 0.86±0.225 ） mg / L in male and （ 0.81±0.218 ） mg / L in female.In youth group , the level was （ 0.87±0.192 ） mg / L in male and （ 0.83±0.202 ） mg / L in female , respectively.In middle age group , the level was （ 0.93±0.200 ） mg / L in male and （ 0.85±0.199 ） mg / L in female.In old age group , the level was （ 1.07±0.216 ） mg / L in male and （ 1.00±0.219 ） mg / L in female.The levels of serum cystatin C were no different between children and youth Group （ P0.05 ）, with significant differences between children , middle age and old age groups （ P0.01 ）, and with gender difference in children group （ P0.01 ） .Conclusion The reference range of serum cystatin C in children was 0.42-1.30mg / L for male and 0.38-1.24mg / L for female.