136例育龄妇女血清抗苗勒管激素检测分析

Detection of serum levels of anti-Müllerian hormone in 136 women of childbearing age

目的探讨月经正常的育龄妇女血清抗苗勒管激素(AMH)水平变化。方法选择136例月经正常的育龄期妇女,按年龄分成5组,于黄体中期测定AMH及其他6种生殖激素。结果 21～25、26～30、31～35、36～40、41～45岁组血清AMH水平分别为5.67、4.26、4.62、1.72、0.56ng/mL,不同年龄组血清AMH水平比较差异有统计学意义(H=25.454,P=0.000);血清AMH与年龄呈负相关,差异有统计学意义(r=-0.385,P=0.000);血清AMH与其他6项激素间均无相关关系(P>0.05)。结论测量育龄妇女血清AMH水平,为了解不孕妇女生育潜力和卵巢功能大概持续时间提供参考。

Objective To explore the serum anti-Mollerian hormone（AMH） levels in women of childbearing age with normal menstrual cycle. Methods 136 women of childbearing age with normal menstrual cycle were selected and divided into 5 groups ac- cording to their ages. Serum levels of AMH and other 6 kinds of reproductive were determinated in corpora luteum metaphase. Re- sults The comparison of serum AMH levels in different age groups had significant difference. （P=0. 000）. The serum AMH level and age showed a significant negative correlation with significant difference. （r=-0. 385 ,P=0. 000）. There was no correlation be- tween the serum levels of AMH and the other 6 kinds of hormones（P〉0. 05）. Conclusion AMH determination for women of childbearing age can provide reference for the evaluation of reproductive potential of infertile women and duration time of ovarian function.