期刊文献+

糖化清蛋白检测临床意义研究进展 被引量:7

下载PDF
导出
摘要 与非糖尿病(NDM)个体相比,糖尿病(DM)患者体内多种蛋白质可发生糖化作用,其中部分糖化蛋白质被认为与DM慢性并发症有关[1-2].在众多的糖化蛋白质中,糖化血红蛋白(HbA1c)被认为是判断DM患者血糖控制水平的金指标[3-4].糖尿病控制与并发症试验(DCTT)研究结果认为,HbA1c<7.0%是用于判断DM慢性并发症的理想指标[5].红细胞的生存周期一般为120 d,因此HbA1c水平反映的是几个月前的血糖含量[6].当在较短的时间内血糖控制水平出现波动时,HbA1c检测并不能反映血糖控制的真实水平.而且,HbA1c水平受红细胞生存周期的影响较大,尤其是当血红蛋白变异或其他疾病(如溶血性贫血、肾性贫血等)导致红细胞生存周期缩短时.
机构地区 解放军第
出处 《国际检验医学杂志》 CAS 2012年第18期2226-2229,共4页 International Journal of Laboratory Medicine
  • 相关文献

参考文献48

  • 1Taniguchi N. Initial reaction of protein glycation[A].Tokyo,Japan:Igaku-Shoin,2007.2-8.
  • 2Cohen MP. Nonenzymatic glycation:a central mechanism in diabetic microvasculopathy[J].Journal of Diabetes and its Complications,1988,(04):214-217.
  • 3Koenig RJ,Peterson CM,Jones RL. Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus[J].New England Journal of Medicine,1976,(08):417-420.
  • 4Bunn HF,Gabbay KH,Gallop PM. The glycosylation of hemoglobin:relevance to diabetes mellitus[J].Science,1978,(01):21-27.
  • 5The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus[J].New England Journal of Medicine,1993,(06):977-986.
  • 6Tahara Y,Shima K. Kinetics of HbA1c,glycated albumin,and fructosamine and analysis of their weight functions against preceding plasma glucose level[J].Diabetes Care,1995,(04):440-447.doi:10.2337/diacare.18.4.440.
  • 7Panzer S,Kronik G,Lechner K. Glycosylated hemoglobin′s (GHb):an index of red cell survival[J].Blood,1982,(10):1348-1350.
  • 8Jeffcoate SL. Diabetes control and complications:the role of glycated haemoglobin,25 years on[J].Diabetic Medicine,2004,(04):657-665.
  • 9Bry L,Chen PC,Sacks DB. Effects of hemoglobin variants and chemically modified derivatives on assays for glycohemoglobin[J].Clinical Chemistry,2001,(02):153-163.
  • 10Armbruster DA. Fructosamine:structure,analysis,and clinical usefulness[J].Clinical Chemistry,1987,(12):2153-2163.

同被引文献58

  • 1杨玉霞.糖化血红蛋白检测方法评价[J].中外健康文摘:临床医师,2008,0(7):69-69. 被引量:1
  • 2中国血糖监测临床应用指南(2011年版)[J].中国医学前沿杂志(电子版),2011,3(4):62-72. 被引量:27
  • 3沈霞,王连升,黎明.酶法测定糖化白蛋白及其临床意义[J].检验医学,2006,21(2):132-135. 被引量:19
  • 4中华医学会检验分会.中华检验医学杂志编辑委员会,卫生部临床检验中心,糖尿病诊断治疗中实验室检测项目的应用建议.中华检验医学杂志,2010,12:33-33.
  • 5中华医学会糖尿病学分会.中国2型糖尿病防治指南[M].北京:北京大学医学出版社,2011:15-16.
  • 6American Diabetes Association. Diagnosis and classification of dia- betes mellitus[J]. Diab Car,2013,34(Suppl 1) :$62 $69.
  • 7Yamaguchi M,Kambe S,Eto T,et al. Point of care testing system via enzymatic method {or the rapid, efficient assay o{ glycated al bumin[J]. Biosens bioelectron. 2005,21 (3) 426-432.
  • 8Reichard P, Nilsson BY, Rosenqvist U. The effect of long term in- tensified insulin treatment on the development of microvascular complications Of diabetes mellitus[J]. N Engl J Med, 1993,329 (5) :304 309.
  • 9UKPDS Group. Intensive blood-glucose control with sulphonylureas or insulin of complications UK Prospective 1998,352(9131) compared with conventional treatment and risk in patients with type 2 diabetes (UKPDS 33). Diabetes Study (UKPDS) Group[J]. Lancet, ,837--853.
  • 10Ma XJ,Pan J M, Bao YQ, et al. Combined assessment of glycated albumin and fasting plasma glucose improves the detection of dia- betes in Chinese subjects[J]. Clin Exp Pharmacol Physiol, 2010, 37 (10) 974-979.

引证文献7

二级引证文献34

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部