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消化道肿瘤患者多联肿瘤标志物联合检测临床意义分析 被引量:6

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摘要 目的探讨多肿瘤标志物蛋白芯片诊断系统在消化道肿瘤临床诊断中的应用价值。方法应用Luminex100测定240例消化道肿瘤患者、100例消化道良性疾病患者血清糖类抗原242(CA242)、糖类抗原125(CA125)、甲胎蛋白(AFP)、癌胚抗原(CEA)和细胞角蛋白19(CY-211)含量,分析其诊断灵敏度和特异度。结果多肿瘤标志物联合检测对消化道肿瘤的诊断灵敏度高于各指标单独检测(P<0.05);胃癌、肝癌、结直肠癌患者血清AFP、CA242、CA125、CEA和CY-211含量高于消化道良性疾病患者(P<0.05)。结论多肿瘤标志物蛋白芯片检测系统的应用对消化道肿瘤诊断有较高的临床参考价值,可提高诊断灵敏度,适用于健康人群、肿瘤高危人群筛查及患者预后和疗效判断。
出处 《国际检验医学杂志》 CAS 2012年第18期2271-2272,共2页 International Journal of Laboratory Medicine
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  • 1高海锋.肿瘤标记物CA125检测对肺癌的诊断价值[J].现代肿瘤医学,2008,16(11):1899-1900. 被引量:9
  • 2唐步坚,李力,许进,吴继宁,古明华,陈心秋,谢肖兰,李菲,张洁清.卵巢肿瘤患者血清乳酸脱氢酶等指标测定[J].中华妇产科杂志,1994,29(6):336-339. 被引量:19
  • 3[2]Paweletz CP,Gilespie JW,Ornstein DK,et al.Rapid protein display profiling of cancer progression directly from human tissue using a protein biochip[J].Drug Dev Res,2000,49(1):34-42.
  • 4[3]von Eggeling F,Davies H,Lomas L,et al.Tissue-specific microdissection coupled with proteinChip array technologies:applications in cancer research[J].Biotechniques,2000,29(5):1066-1070.
  • 5Eggeling F,Davies H,Lomas L,et al.Tissue-specific microdissection coupled with protein-chip array technologies:application in cancer research[J].Biotechniques,2005,29(1):1066-1069.
  • 6Visintin I,Feng Z,Longton G,et al.Diagnostic markers for early detection of ovarian cancer[J].Clin Cancer Res,2008,14(4):1065-1072.
  • 7Juretzka MM,Barakat RR,Chi DS,et al.CA125 level as a predictor of progression-free survival and overall survival in ovarian cancer patients with surgically defined disease status prior to the initiation of intraperitoneal consolidation therapy[J].Gynecol Oncol,2008,108(2):336-341.
  • 8Rocconi RP,Mattews KS,Kemper MK,et al.Chemotherapy related myelosuppression as a marker of survival in epithelial ovarian cancer patients[J].Gynecol Oncol,2007,104(1):176-180.
  • 9Yurkovetsky ZR,Linkov FY,Malehorn DE,et al.Multiple biomarker panels for early detection of ovarian cancer[J].Future Oncol,2006,2(6):733-741.
  • 10Bast RC,Badgwell D,Lu Z,et al.New tumor markers:CA125 and beyond[J].Int J Gynecol Cancer,2005,15(3):264-271.

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