期刊文献+

血清胃蛋白酶原ELISA法检测参考范围探讨 被引量:5

下载PDF
导出
摘要 目的探讨酶联免疫吸附法(ELISA)检测血清胃蛋白酶(PG)的参考范围。方法采用ELISA双抗体夹心法检测3 257例健康者血清PGⅠ、PGⅡ含量,并计算PGⅠ/PGⅡ比值。结果各年龄段PGⅠ、PGⅡ比较差异无统计学意义(P>0.05),PGⅠ/PGⅡ比值比较差异有统计学意义(P<0.05);男、女性PGⅠ和PGⅠ/PGⅡ比值比较差异无统计学意义(P>0.05),PGⅡ检测结果比较差异有统计学意义(P<0.05)。结论本实验室PGⅠ、PGⅡ和PGⅠ/PGⅡ参考范围分别为69.53~176.22、1.70~27.46μg/L和5.22~63.83。PG检测可作为胃癌初筛、幽门螺杆菌根除治疗效果评价指标,与慢性胃炎和消化性溃疡具有一定相关性。
出处 《国际检验医学杂志》 CAS 2012年第18期2284-2285,共2页 International Journal of Laboratory Medicine
  • 相关文献

参考文献10

  • 1Samloff IM. Pepsinogens I and II:purification from gastric mucosa and radioimmunoassay in serum[J].Gastroenterology,1982,(01):26-33.
  • 2陈智周,范振符.胃蛋白酶原Ⅰ、Ⅱ在早期胃癌普查中的意义[J].中华肿瘤杂志,2002,24(1):1-3. 被引量:90
  • 3赵水娣,李彬,贾宁人.血清胃蛋白酶原临床检测中的稳定性分析[J].国际检验医学杂志,2011,32(20):2395-2397. 被引量:2
  • 4Pisani P,Parkin DM,Bray F. Estimates of the worldwide mortality from 25 cancers in 1990[J].International Journal of Cancer,1999,(01):18-29.
  • 5吴云林;涂水平.早期胃癌的筛选[J]中国实用内科杂志,1996(04):387-388.
  • 6Furuta T,Kaneko E,Baba S. Percentage changes in serum pepsinogens are useful as indices of eradication of Helicobacter pylori[J].American Journal of Gastroenterology,1997,(01):84-88.
  • 7Abnet CC,Zheng W,Ye W. Plasma pepsinogens,antibodies against Helicobacter pylori,and risk of gastric cancer in the Shanghai Women′s Health Study Cohort[J].British Journal of Cancer,2011,(09):1511-1516.doi:10.1038/bjc.2011.77.
  • 8Cook MB,Dawsey SM,Diaw L. Serum pepsinogens and Helicobacter pylori in relation to the risk of esophageal squamous cell carcinoma in the alpha-tocopherol,beta-carotene cancer prevention study[J].Cancer Epidemiology Biomarkers and Prevention,2010,(08):1966-1975.doi:10.1158/1055-9965.EPI-10-0270.
  • 9Irvani S,Hashemi MR,Moghadam KG. Accuracy of serum pepsinogens I and II,gastrin-17 and anti-helicobacter pylori antibodies in histological diagnoses of atrophic gastritis[J].Minerva Gastroenterologica E Dietologica,2010,(01):13-17.doi:10.1111/j.1532-849X.2011.00745.x.
  • 10Di Mario F,Cavallaro LG,Moussa AM. Usefulness of serum pepsinogens in Helicobacter pylori chronic gastritis:relationship with inflammation,activity,and density of the bacterium[J].Digestive Diseases and Sciences,2006,(10):1791-1795.doi:10.1007/s10620-006-9206-1.

二级参考文献8

共引文献90

同被引文献26

引证文献5

二级引证文献35

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部