双吡啶硫酮的合成改进

IMPROVED SYNTHESIS OF DIPYRITHION

以2-巯基吡啶-N-氧化物为原料,30%过氧化氢-尿素加合物为氧化剂合成了双吡啶硫酮,最佳反应条件是:n(原料):n(氧化剂)=1:1.25,反应温度45℃,反应时间1.75 h。粗产物用乙醇重结晶,纯度为99.6%,收率为91.6%。并用元素分析、红外光谱和氢核磁共振谱对产物的结构进行了表征。

At the molar ratio of 1 ： 1.25 and the reaction temperature of 45 ~C, Dipyrithion was ob tained through reacting 2-pyridinethiol-N-oxide with 30% hydrogen peroxide-urea adduct for 1.75 h. The yield and purity were 91.6% and 99.6% respectively. The structures were characterized by ele mentary analysis, IR and ^1H NMR.