高级糖基化终末产物在认知功能障碍发病中的作用

Role of advanced glycation end products in pathogenesis of cognitive impairment

高级糖基化终末产物(AGEs)是由蛋白质非酶促化反应生成的不可逆的终产物,高级糖基化终末产物受体(RAGE)是其体内重要的受体。通过临床、动物实验及病理研究发现,AGEs与认知功功能损害的发生有关,对神经细胞的直接毒性作用、对β-淀粉样蛋白(Aβ)、TAU蛋白及a-突触核蛋白(a-Synuclein)等修饰、炎症反应和脑血管损伤是AGEs参与认知损害发生的重要机制。通过药物拮抗AGEs的作用可能是治疗认知障碍的一个有效途径。

Non-enzymatic glycation of proteins by reducing sugars leads to the formation of advanced glycation end products （AGEs）, RAGE acts as an important receptor for AGEs. Clinical, animal and pathology studies show that AGEs are associated with cognitive impairment. The associated pathgenesis of cognitive impairment with AGEs mainly include direct a-Synuclein, Inflammation and cerebrovascular impairment minimizing the effect of AGEs. toxic effects, modification of TAU, A[3 and AGE-inhibitors may be a promising approach for