垂体柄阻断综合征的MRI特征及相关临床分析

Clinical and MRI features of pituitary stalk interruption syndrome

目的:分析垂体柄阻断综合征(PSIS)临床表现、实验室检查及特征性MRI的影像改变,提高本病的早期诊断。方法:回顾性分析我院15例PSIS患者的临床表现、实验室检查及MRI影像学特点,结合文献分析其表现。结果:MRI可直接显示垂体后叶异位,多高位于下丘脑漏斗处,垂体柄缺如,垂体前叶低伏于垂体窝底;实验室检查均有生长激素和(或)其他激素的缺乏。结论:MRI检查是垂体柄阻断综合征诊断的解剖学依据,结合其临床表现、实验室检查,可以早期对本病作出正确诊断。

Objective： To analyze the clinical manifestations, laboratory findings and magnetic resonance imaging （MRI） features of pituitary stalk interruption syndrome（PSIS） for improving its early diagnosis. Methods： The clinical data were retrospectively analyzed, together with literature re- view, in 15 patients with PSIS regarding the clinical pictures, laboratory findings and MRI characterization. Results：MRI examination was compe- tent to totally expose the ectopic posterior pituitary and revealed the pitui- tary lobe at infundibulum stem, with disappearance of the pituitary stalk. The anterior pituitary was seen within the pituitary fossa. Laboratory find- ings suggested deficiency of growth hormone and/or other hormone in the total cases. Conclusion ： MRI may serve the most valuable anatomy base for the diagnosis of PSIS, and accurate diagnosis of this entity can rely on laboratory findings and its clinical manifestations.