稽留流产患者绒毛组织中缺氧诱导因子(HIF)-1α的表达及意义

Expression of Hypoxia-inducible Factor-1α in the Villi of Missed Abortion Patients

目的:探讨稽留流产绒毛组织中缺氧诱导因子-1α(HIF-1α)的表达及临床意义。方法:经B超及β-hCG动态监测证实为稽留流产患者30例,选取同期经B超证实为活胎,因非意愿妊娠在门诊要求行人工流产的早孕妇女30例为对照组。采用免疫组织化学方法比较两组绒毛组织中HIF-1α的表达。结果:HIF-1α的表达主要位于绒毛滋养细胞胞浆和胞核;与正常早孕妇女绒毛组织相比较,稽留流产绒毛组织中HIF-1α的阳性表达明显低于对照组(P<0.01)。结论:HIF-1α在绒毛组织中的低表达可能与胚胎停育相关。

Objective： To explore the effect of hypoxia-inducible factor-1α（HIF-1α） in villi of missed abortion patients. Methods： The expression of HIF-1α was detected in villi of missed abortion patients of 30 cases,and normal early pregnant women of 30 cases by immunohistochemistry.Results： The expression of HIF-1α in villi of missed abortion patients was lower than that in normal early pregnant woman（P 0.05）.Conclusion： The low expression of HIF-1αin villi is a factor related with missed abortion.