胃癌中EGFR、HER2及GST-π的表达及临床意义

Expressions and significance of EGFR,HER2 and GST-π in human gastric carcinoma

目的探讨胃癌组织中人表皮生长因子受体(EGFR)、表皮生长因子受体-2(HER2)、和胎盘型谷胱甘肽-S-转移酶-π(GST-π)的表达及与临床病理特征的关系。方法应用免疫组化Envision二步法,检测70例胃癌组织EGFR、HER2和GST-π的表达情况,并结合其临床病理特点进行分析。结果 EGFR、HER2和GST-π在胃癌组织中的表达阳性率分别为35.7%(25/70)、27.1%(19/70)和58.6%(41/70)。阳性表达与肿瘤分化程度,侵袭深度,有无淋巴结转移及TNM分期有关(P<0.05),而与患者的性别及年龄、肿瘤部位和大小无关(P>0.05)。EGFR、HER2和GST-π三者之间在胃癌组织中的表达均呈正相关(P<0.05)。结论 EGFR、HER2和GST-π的表达参与胃癌的生长、侵袭和转移过程。它们的联合检测有助于胃癌患者靶向药物联合化疗药物的初筛及对胃癌患者的预后评价。

Objective To investigate the expressions of EGFR, HER2 and GST-π in human gastric carcinoma and to study the relationship among them and the elinicopathological factors of gastric carcinoma. Methods The Envision immunohisto- chemical stain method was used to detect EGFR, HER2 and GST-π protein expressions in sample of 70 gastric carcinoma tissues. And their corresponding clinical data were analyzed retrospectively. Results The positive expression rates of EGFR , HER2 and GST-π protein in gastric carcinoma tissues were 35.7% （25/70） ,27. 1% （19/70） and 58.6% （41/70）. The positive expression rates were closely relevant to tile differentiation of the carcinoma, invasion depth, lymphatic metastasis and TNM（ P 〈 0. 05 ） , but not to the patient＇s sex, age, tumor site and size （P 〉0.05）. There was a stable positive correlation among EGFR , HEir2 and GST-π expressions in gastric carcinoma tissues, respectively. Conclusion EGFR, HER2 and GST-π expressions participate in the development, invasion and metastasis process of gastric carcinoma. Joint detection of them can be looked as a primary detection for guiding the molecular targeting therapy and chemotherapy of gastric carcinoum, and judging the prognosis of gastric carcinoma