异甘草酸镁治疗药物性肝损害的临床疗效观察

Exploration of therapeutic effects of Magnesuim Isoglycyrrhizinate on drug-induced liver injury

目的探讨异甘草酸镁治疗药物性肝损害的临床疗效。方法观察组以异甘草酸镁治疗药物性肝损害100例,对照组以甘草酸二铵治疗药物性肝损害100例,观察两组治疗前后症状、体征以及肝功能血清丙氨酸转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、血清总胆红素(TBIL)、γ-谷氨酰转肽酶(GGT)和碱性磷酸酶(ALP)的变化情况,以及两组患者住院天数的差异。结果与对照组相比,异甘草酸镁可明显改善药物性肝损害患者肝功能指标(P均<0.05),住院天数显著缩短(P<0.01)。结论异甘草酸镁治疗急性药物性肝损害的效果较好,值得临床推广使用。

Objective To explore the therapeutic effects of Magnesium lsoglycyrrhizmate on resistance against drag-re- duced liver injury. Methods 200 patients in hospital were randomly divided into treatment group（ 100 cases） and control group （ 100 cases）. The changes between pre-treatment and post-lreatmcnt in ALl＇, AS＇F, TBII,, GGT, ALP and inpatient days were ob served. Results Compared with control group, the liver function indices of lreatmcnt grotp improved obviously （ P 〈 0.05 ） and the impatient days were shorter as well （ P 〈0. Ol ）. Conclusion The Magnesuim lsoglycyrrhizma/e has excellent effects on resist- ance against drug-induced liver injury. It is worthy of further clinical application.