膀胱灌注羟基喜树碱预防浅表性膀胱癌术后复发的临床观察

The effect of intravesical instillation of hydroxycamptothecin to prevent recurrence after surgical treatment of superficial bladder tumor

目的探讨膀胱灌注羟基喜树碱预防浅表性膀胱癌术后复发的临床效果和安全性。方法两组患者均采用经尿道气化电切术治疗原发性肿瘤,观察组给予羟基喜树碱膀胱灌注化疗,对照组采用丝裂霉素,对患者进行随访,了解复发情况和不良反应等。结果两组患者术后均得到随访,随访时间为24～36个月,术后3个月(2.50%VS 5.00%)和6个月(7.50%VS 10.00%)两组患者肿瘤复发率比较,差异无统计学意义(P>0.05);但是12个月(10.00%VS30.00%)和24个月(17.50%VS 37.50%)肿瘤复发率比较,差异有统计学意义(P<0.05)。观察组患者不良反应发生率22.50%,对照组不良反应发生率72.50%,差异有统计学意义(P<0.05)。结论浅表性膀胱癌术后给予羟基喜树碱膀胱灌注化疗,可以有效预防肿瘤复发,安全性高,是一种有效预防浅表性膀胱癌术后复发的药物。

Objective To explore clinical effectiveness and safty of hydroxycamptothecin to prevent recurrence at＇let surgi- cal treatment of superficial bladder tumor. Methods All patients were treated with transurethral electrosurgical excision proce- dure. The observation group was treated with intravesical instillation of hydroxycamptotheein; and the control group was treated with Mitomyein C. All the patients were followed up for 24 ～ 36 months, in order to evaluate the recurrence rates and side effects after treatment. Results The recurrence rate of two group patients follow-up of 3 months（2. 50% VS 5.00% ） and follow-up of 6 months（7.50% VS 10. 00% ）has no significant difference（P 〉 0. 05）. The recurrence rate of two group patients follow-up of 12 months（ 10.00% VS 30. 00% ） and follow-up of 24 months （ 17. 50% VS 37. 50% ） has statistically significant difference （ P 〈 0. 05 ）. The side effects rate in observation group is 22. 50%, and 72. 50% in control group, tile difference was statistically signif- icant （P 〈0. 05）. Conclusion It showed that hydroxyeampt0thecine intravesical instillation after operation is effective and salty in the prevent of recurrence of superficial bladder tumor.