COPD急性发作期患者血尿酸水平的变化及临床意义

The detection of serum uric acid in chronic obstructive pulmonary disease with acute exacerbation and its clinical significance

目的检测慢性阻塞性肺疾病(COPD)急性发作期患者血尿酸水平的变化,并探讨了其相关的临床意义。方法收集我院2010年12月～2011年12月收治的COPD急性发作期患者64例,将COPD患者按严重程度分为Ⅰ、Ⅱ、Ⅲ、Ⅳ四级。另取本院体检中心的健康体检者20例作为对照组。生化分析仪检测血尿酸水平的变化。结果对照组和COPD急性发作期组血尿酸的水平分别为(264.32±46.46)和(410.54±87.36)μmol/L,COPD急性发作期患者血尿酸的水平显著高于对照组(P<0.01)。COPD急性发作期患者经过积极治疗后血尿酸的水平从(410.54±87.36)μmol/L降低到(324.44±62.47)μmol/L,两者间差异有统计学意义(P<0.05)。COPDⅠ、Ⅱ、Ⅲ和Ⅳ级患者血尿酸的水平分别为(286.74±50.12)、(352.16±59.14)、(432.66±80.34)和(484.57±92.64)μmol/L,各组间差异有统计学意义(P<0.05)。结论COPD急性发作期患者存在血尿酸水平的升高,升高的血尿酸可以用于COPD急性加重期患者病情的监控。

Objective To investigate the changes of serum uric acid in chronic obstructive pulmonary disease （COPD） with acute exacerbation and its clinical significance. Methods A total of 64 acute exacerbated COPD patients were enrolled in this study. All the acute exacerbated COPD patients were derided into Ⅰ、Ⅱ、Ⅲ and IV level. Another 20 heahhy person were used as a control. The expression of serum uric acid was statistically analyzed among tile difference groups. Results The expression of so- ruin uric acid was（ 264. 32 ± 46.46 ） and （ 410. 54 ± 87.36 ）μmol/L in control and acute exacerbated COPD group, respectively. There was signicifant difference between the two groups（ P 〈 0. 01 ）. After treatment, the expression of serum uric acid was de- creased from（ 410. 54 ± 87. 36 ）to（ 324. 44 ±62.47 ）μmol/L. There was signicifant difference between the two groups （P 〈 0.05 ）. The expression of serum uric acid inⅠ、Ⅱ、Ⅲand IV group was （ 286. 74 ± 50. 12 ） , （ 352. 16 ±59. 14） , （432. 66 ± 80. 34 ） and （484. 57 ± 92. 64） μmol/L, respectively. There was signicifant difference among the different groups （ P 〈 0. 05 ）. Conclusion The expression of serum uric acid was increased in acute exacerbated COPD patients, and which could be used as a factor to motli- tore the disease.