去游离甘油三酰甘油对Friedewald公式计算低密度脂蛋白胆固醇的影响

To investigate the impact of triglyceride freed glycerol for low density lipoprotein cholesterol concentration calculated by Friedewald formula

目的评估去游离甘油三酰甘油对Friedewald公式计算低密度脂蛋白胆固醇的影响。方法样本来源于本院就诊患者,共5302例。测定其血清总胆固醇、高密度脂蛋白胆固醇及低密度脂蛋白胆固醇浓度(LDL-C),用去除游离甘油的方法测定血清三酰甘油浓度(TG),纳入TG≤4.51mmol/L的样本5016例,用Friedewald公式(F公式)计算其低密度脂蛋白胆固醇浓度[(LDL-C(F)],与直接法测定的LDL-C浓度[(LDL-C(M)]进行比较。依据美国国家胆固醇教育计划(NCEP)对TG和LDLC分组。结果 LDL-C(F)与LDL-C(M)在TG正常组(%=0.880)、TG边缘升高组(%=0.943)和TG升高组(%=0.897)都显示了良好的相关性(P<0.01)。TG正常组、TG边缘升高组和TG升高组的LDL-C(F)都明显高于LDL-C(M)(P<0.001)。在NCEP危险度分类中LDL-C(F)与LDL-C(M)的一致性平均为77.4%。结论用F公式计算LDL-C浓度时,去游离甘油TG会高估LDL-C浓度。

Objective rib evaluate tile impact of triglyceride freed glycerol for low density lipoprotein cholesterol concen- tration calculated by Friedewald formula. Methods Serum total cholesterol （TC） , triglyceride （TG） , high density lipoproten cholesterol （HDL-C） and low density lipoprotein cholesterol （LDL-C）concentrations were measured in 5302 patictlts, TG were measured by glycerol-blanked assay. A total 5016 patients with TG concentrations ≤4.51mmol/1 were enrolled, the LDL-C con- centrations were also calculated by Friedewald formula. Comparison of LDL-C concentrations calculated by the Friedewald foralula （LDL-C（F） ） and measured by direct homogeneous （LDL-C（M） ）assay were performed. The concordances of the National Cho- lesterol Education Program （NCEP） risk category were estimated. Results Both in normal and moderate high and high TG group, LDL-C （F） correlated with LDL-C （M） ： r=0. 880, 0. 943 ,and O. 897 respectively. The mean concentrations of LDL-C （F） were significantly higher than those of LDL-C （M） in normal and moderate high and high TG group. The average of concord- ance for NCEP categories were 77.4%. Conclusion The concentrations of LDL-C （F） were significantly higher than those of LDL-C （M） , when freed glycerol assay were used for measuring TG.