奥曲肽在内镜粘合剂D-TH治疗食管和胃静脉曲张中的应用

Octreotide application in treatment for esophagogastric varices and its bleeding with the tissue adhesive D-TH

目的 探讨奥曲肽在内镜粘合剂D -TH治疗食管和胃静脉曲张中的作用。方法 粘合剂D -TH内镜注射治疗前 5h起静脉维持滴注奥曲肽 0 0 2 5mg/h ,术前 2 0′静脉注射冲击量奥曲肽 0 1mg。内镜直视下注射D -TH液治疗肝硬化食管和胃静脉曲张及其出血。结果 D -TH治疗 7例食管和胃静脉曲张破裂急性出血均获即时止血 ,8例食管和胃粗大曲张静脉注射D -TH和硬化剂治疗均无针孔出血。结论 应用奥曲肽有助于食管和胃静脉曲张及其出血的内镜下D -TH硬化治疗 ,术后维持治疗可有效降低再出血率。粘合剂D -TH能有效控制食管和胃静脉曲张出血 。

Aim To investgate the effect of octreotide in treatment for esophagogastric varices with the tissue adhesive D TH under endoscopy.Methods Before 5 hours of endoscopic injection with D TH,Octreotide was infused 0.025 mg/h intravenously,and octreotide o.1mg would be used about prior 20 minutes of endoscopic intervene,Then esophagogastric varices and its bleeding were treated with D TH through endoscopy.Results Acute vericeal bleeding of 7 cases was controlled immediately after injection of D TH,and bleeding didn't occur on the variceal needle holes while sclerotherapy with D TH in big varices of 8 cases.Conclusion Octreotide is of benefit to the sclerotherapy and hemostasis with D TH in patients with esophagogastric varices,The tissue adhesive D TH can control acute variceal bleeding effectively and avoid the hemorrhage on the needle holes during scleratherapy.