“超级细菌”的耐药性及抗菌新药研发

Antibiotic-resistant "Superbug" and Research of New Anti-bacterial Drugs

近几年,耐药性新型"超级细菌"的屡屡出现,主要是滥用抗生素的结果,这引起了各国科学家和医药工作者的广泛关注。已知细菌的耐药机制主要包括产生灭活酶、改变靶位、主动外运、生物被膜屏障、外膜通透性降低等。目前,生物医药研究人员主要从微生物、动物和中草药中筛选和开发新型抗生素和抗菌药。此外,人工合成抗菌药也日渐兴起。

In recent years, new antibiotic-resistant ＂ superbugs＂ frequently appeared because of the misuse of antibiotics so that scientists and medical workers in all countries worried. Bacterial drug-re- sistance mechanisms included produce inactivated enzyme, change targets, active Sinotrans, biofilm barrier, decreased outer membrane permeability and so on. At present ,researchers screen new antibi- otics and antibacterial agents mainly from microorganisms, animals and Chinese herbal medicine. In addition, synthetic antimicrobial agents are increasingly emerging.