低剂量米非司酮用于紧急避孕临床观察

A Clinical Study on Mifepristone at Low Dose for Emergency Contraception.

目的:进一步确认米非司酮25mg用于紧急避孕的有效性。在全国11个省市的计划生育技术指导站及综合医院妇产科观察了622例紧急避孕的临床效果,均为避孕失败或无保护性生活后72小时内就诊并符合条件的健康妇女,单次口服米非司酮25mg。结果:失败5例,按Dixon法计算,避孕有效率为91.25％。受试者的月经周期无明显改变且未出现明显副作用。此研究进一步证实米非司酮25mg单次口服可作为理想的紧急避孕药物。

To evaluate the effectiveness of low dose mifepristone for emergency contraception 622 cases have been studied on the clinical effectiveness of emergency contraception in the Family Planning Service Centers and Hospitals in 11 provinces in China. The subjects, who had unprotected intercourse or contraceptive failures, took a single dose of 25mg. Mifepristone 72 hours after the inter-couse. 5 cases failed, the contraceptive effective rate was 91. 25% by Dixon. All the subjects had no evident changes in the length of the cycle and no evident side effect resulted. It was suggested that 25mg mifepristone at a single dose in the most effective for emergency contraception.