摘要
目的 :探讨大肠癌CD4 4 V6,E cadherin的表达对大肠癌的进展和转移的意义。方法 :应用SP免疫组化技术检测 56例大肠癌标本的CD4 4 V6,E cadherin的表达。结果 :CD4 4 V6表达有转移者 84 9%( 2 8/ 33) ,无转移者 39 1% ( 9/ 2 3)。E cadherin表达有转移者 2 4 2 % ( 8/ 2 3) ,无转移者 52 2 % ( 12 / 2 3) ,两者与肿瘤转移明显相关 (P <0 0 5)。结论 :对大肠癌组织进行CD4 4 V6,E cadherin的表达检测 ,有助于预测大肠癌的进展程度和转移的判断 。
Objective:To evaluate the expression of CD 44 V 6 and E cadherin in colorectal cancer and its roles in estimation of tumor progression and metastasis.Methods:Using immuno chemical staining, the expression of CD 44 V 6 and E cadherin was detected in colorectal cancer.Results:The positive rate of CD 44 V 6 is 84.9%(28/33) in tumors with metastasis,and 39.1%(9/33) in tumors without metastasis.The positive rate of the expression of E cadherin is 24.2%(8/23) in tumors with metastasis, and 52.2%(12/23) without metastas.Conclusions:Determination of CD 44 V 6 and E cadheron might be useful in assessing tumor progression and metastasis and in predicting prognosis of colorectal cancer.
出处
《肿瘤防治杂志》
2000年第3期242-244,共3页
China Journal of Cancer Prevention and Treatment
关键词
抗原
粘附分子
免疫组织化学
大肠癌
colonil neoplasms
antigens CD_(44)
E-cadherins
immunohistochemistry
