胶质源性神经营养因子在正常和炎症牙髓组织中的变化

Changes of glial cell line derived neurotrophic factor in normal and inflamed dental pulp

目的 :探讨胶质源性神经营养因子 (GDNF)在牙髓炎症中的表达变化及意义。方法 :应用免疫组织化学方法比较正常和炎症状态下 ,GDNF在牙髓组织中的变化。结果 :正常牙髓组织GDNF染色呈阴性 ,炎性牙髓组织染色GDNF呈阳性 ,其主要分布在牙髓组织成牙本质细胞和成牙本质细胞深层细胞 ,而牙髓神经雪旺氏细胞染色为阴性。结论 :GDNF参与牙髓炎性反应 ,与炎性牙髓组织再生发芽有关。

AIM: To investigate effects of glial cell line derived neurotrophic factor (GDNF) on dental nerve regression during inflamed restoration stages of dental pulp. METHODS: To observe changes of GDNF in inflamed dental pulp, compared with that in normal dental pulp by immunohistochemistry. RESULTS: Expression of GDNF was mainly found in odontoblast layer and subodontoblast zone of inflamed dental pulp, while was not observed at Schwann cell and normal dental pulp. CONCLUSION: These results indicate that GDNF may take part in inflamed response of dental pulp, and have an essential role in nerve sprouting reactions. [