幽门螺杆菌感染对非甾体抗炎药相关性胃炎患者胃黏膜屏障功能的影响

Effects of Helicobacter pylori infection on gastric mucous membrane barrier function in patients with nonsteroidal anti- inflammatory drug- associated gastritis

目的研究幽门螺杆菌（Hp）感染对非甾体抗炎药（NSAIDs）相关性胃炎患者胃黏膜屏障功能的影响。方法回顾分析50例NSAIDs相关性胃炎患者的临床资料，根据有无Hp感染分为H西阳性组及Hp阴性组，每组25例。采用ELISA法测定胃黏膜表皮生长因子（EGF）、白细胞介素8（IL-8），放射免疫法检测胃黏膜前列腺素E2（PGE2）。结果Hp阳性患者与Hp阴性患者比较，EGF、PGE2均明显降低，而IL-8含量则明显升高（P〈0．05）。结论Hp感染致NSAIDs相关性胃炎患者的胃黏膜屏障功能减弱。对于NSAIDs相关性胃炎感染Hp者，须行Hp根除治疗。

Objective To study the effects of Helicobacter pylori （Hp） infection on gastric mucous membrane barri- er function in patients with nonsteroidal anti - inflammatory drug （NSAID） - associated gastritis. Methods The clinical data of 50 NSAID - associated gastritis patients were reviewed and analyzed retrospectively. 50 patients were divided into Hp positive group and Hp negative group according to Hp infection （n =25 each）. The levels of gastric mucosa epider- mal growth factor （EGF） and IL -8 were measured by ELISA and the levels of gastric mucosa PGE2 were measured by RIA. Results Compared with Hp negative group, the levels of gastric mucosa EGF and PGE2 significantly decreased while the levels of gastric mucosa IL - 8 significantly increased in Hp positive group （P 〈 0.05）. Conclusion It is clear that Hp can change gastric mucous membrane barrier function in patients with NSAID - associated gastritis. It is necessary to eradicate Hp in Hp infection patients with NSAID -associated gastritis.