摘要
对小叶女贞叶片提取物进行体外抗菌、细胞毒性以及抗氧化药用活性研究,结果表明,小叶女贞叶片提取物对铜绿假单胞菌PAO1具有较强的抑制作用,最小抑制浓度(MIC)为8.0 mg/mL;对人肝癌细胞BEL-7404体外增殖具有显著的抑制作用,浓度在0.6 mg/mL时,抑制率达94.2%;同时具有较强的DPPH自由基清除能力,浓度为15.1μg/mL时,清除率为85.9%。活性跟踪测试表明,小叶女贞叶片提取物干柱层析得到的各组分中,低极性组分Fr.1为活性部分。
The aqueous extract of Ligustrum quihoui leaves was tested for antibacterial,cytotoxic and antioxidant activities.The results indicated that the aqueous extract possessed a notable inhibitory effect toward Pseudomonas aeruginosa PAO1 with MIC 8.0 mg/mL.MTT assay showed that the aqueous extract presented significant inhibition on proliferation of human hepatocellular carcinoma cell BEL-7404,with an inhibitory rate of 94.2% at the concentration of 0.6 mg/mL.And the results of antioxidant activity showed that the aqueous extract exhibited strong scavenging capacity,with a DPPH clearance rate of 85.9% at the concentration of 15.1 g/mL.
出处
《武夷科学》
2012年第1期128-132,共5页
Wuyi Science Journal
基金
教育部博士点基金(20093515120005)
福建省自然基金资助项目(2012J01088)
福建省科技厅重点项目(2009N0016)
关键词
小叶女贞
抑菌
细胞毒
抗氧化
Ligustrum quihoui Carr.
Antibacterial
Cytotoxicity
Antioxidant
