血浆β-TG、PF_4的变化在急性脑梗死与多灶性脑梗死中的意义探讨

PROBING INTO THE SIGNIFICANCE OF PLASMA LEVELS OF β-TG AND PF4 IN ACUTECEREBRAL INFARCTION

探讨血浆 β -血小板球蛋白 (β -TG)、血小板 4因子 (PF4)在急性脑梗死 (ACI)病人中的动态变化。方法 :采用酶标免疫测定法测定 4 0例ACI患者 6～ 72h、7d和 3 3例多灶性脑梗死患者血浆 β -TG、PF4 的变化。结果 :发现ACI组 6～ 72hβ -TG和PF4 、7d后PF4 及多灶性脑梗死组PF4 均高于对照组 (P <0 .0 1) ,且ACI组 7d后PF4 较 6～ 72h显著下降 (P <0 .0 1) ,但仍高于对照组 (P <0 .0 1) ;ACI组 7d后 β -TG与多灶性脑梗死组、对照组均无差异 (P >0 .0 5)。这些变化与病灶的大小无明显正相关 ,多灶性脑梗死组病灶愈多 ,PF4 愈高 (P <0 .0 5)。结论 :本研究提示脑梗死病人血小板活性增高 ,β -TG、PF4 均升高可能为ACI 6～ 72h患者 ,仅有PF4 升高可能为多灶性脑梗死。因此 ,可将 β -TG、PF4 的改变 ,作为缺血性脑血管病分类判断指标之一。

Objective: To study the motional changes between β-thromboglobulin (β-TG), platelet factor 4 (PF4 ) in plasma and the patients with acute cerebral infarction (ACI). Methods: This research adopted Enzyme Immunological Assay measure plasma levels ofβ-TG, PF4 in 40 ACI and 33 multi-focus cerebral infarction patients. Results: Found that β-TG, PF4 of ACI group in 6-72h, PF4 after 7 days and PF4 of multi-focus cerebral infarction are all higher than control group (P<0.01). Found that PF4 in ACI group after 7 days is obviously slower than that in 6-72h (P<0.01), and still higher than the control group (P<0.01). And also, levels of plasma β-TG in ATCI group after 7 days, multi-focus cerebral infarction and the control group were not obviously different (P>0.05). These changes and sizes of focus were not positively correlated. The more focus in multi-focus cerebral infarction is, the higher PF4 is (P<0.05). Conclusions: The study shows platelet activity of cerebral infarction patients increases. The elevation of β-TG, PF4 may be the ACI patients in 6-72h, only the increase in plasma PF4 may be multi-focus cerebral infarction. So, the levels of plasma β-TG, PF4 can be one of the decisive index of classification in ischemic cerebrovascular disease.