蒙古族人群炎症标志物与胰岛素敏感指数的相关性研究

Association between biomarkers of inflammation and insulin sensitivity index among Mongolian population

目的探讨蒙古族人群炎症标志物C反应蛋白(CRP)、可溶性E选择素(sE-selectin)和可溶性细胞黏附分子(sICAM-1)与胰岛素敏感指数(ISI)的关系。方法以年龄≥20岁蒙古族居民作为研究对象,采取调查问卷方式收集人口统计学特征和生活方式危险因素资料,测量身高、体质量和血压,检测血脂、血糖、胰岛素和CRP、sE-se-lectin、sICAM-1等炎症标志物等指标。采用Logistic回归分析炎症标志物水平与ISI降低的关联关系。结果经多因素调整后,随着CRP和sE-selectin水平的升高,ISI降低的危险度呈升高趋势(P<0.05)。以最低分位为参比,最高分位CRP和sE-selectin者的ISI降低(ISI≤0.0130)的OR值(95%可信区间)为1.324(0.990～1.771)和1.986(1.486～2.654)。而sICAM-1水平升高与ISI降低的危险性无关联关系(P>0.05)。结论 CRP和sE-selectin水平升高与ISI降低的危险性相关联。

Objective To explore the association between the biomarkers of inflammation including C-reactive protein （ CRP）, soluble E-selectin （sE-seleetin） and soluble inter-cellular adhesion molecule-1 （sICAM-1） and insulin sensitivity index （ISI） in Mongolian population. Methods Mongolian residents aged 20 and above were served as study subjects. Demographic characteristics and lifestyle risk factors were investigated by the questionnaire, and their body height, weight and blood pressure were measured, and blood lipids, blood glucose, insulin and inflammatory markers etc, were examined for all subjects. Multivariate logistic regression analysis were used to estimate the association between the biomarkers of in- flammation and insulin sensitivity index. Results Among the Mongolian residents, the risk of decreased ISI （ ISI ≤ 0. 0130 ） was significantly increased （ P 〈 0.05 ） with increased CRP. Compared to lowest quartile of CRP and sE-selectin, odds ratio （95% confidence interval） of decreased ISI associated with highest quartile of CRP and sE-selectin were 1. 324（0.990 - 1. 771 ） and 1. 986（ 1. 486 - 2. 654）, re- spectively. However, there was no significant association between increased sICAM-1 and decreased ISI.Conclusion Increased C-reactive protein and sE-selectin were associated with decreased ISI among Mongolian population.