高敏C反应蛋白、同型半胱氨酸、颈动脉粥样硬化斑块与进展性脑梗死的相关性分析

Study on the relation between high-sensitivity C-reactive protein,homocysteine and carotid atteriosclerosis in patients with progressive ischemic stroke

目的探讨血清高敏C反应蛋白、同型半胱氨酸及颈动脉粥样硬化与进展性脑梗死发生的相关性。方法应用免疫比浊法和荧光偏振免疫分析法对80例进展性脑梗死患者、98例非进展性脑梗死患者进行血清高敏C反应蛋白、同型半胱氨酸水平测定、颈动脉彩色多普勒超声检查,并与90例健康体检者作比较。结果进展性脑梗死组血清高敏C反应蛋白、同型半胱氨酸及颈动脉IMT最高,对比非进展性脑梗死组和健康对照组,差异有统计学意义(P<0.05);且进展性脑梗死组血清高敏C反应蛋白、同型半胱氨酸与颈动脉IMT呈显著正相关(r=0.6183,r=0.5862,P<0.01)。结论血清高敏C反应蛋白、同型半胱氨酸水平越高,颈动脉粥样硬化越重,容易促使梗死进展加重。

Objective To investigate the relationship between C-reactive protein（hs-CRP）,homocysteine（Hcy） and carotid arteriosclerosis in progressive ischemic stroke（PIS）.Methods hs-CRP（with immunoturbidimetry）,Hcy（with fluorescence polarization immunoassay） levels were measured in 80 patients with PIS and 98 patients with non-PIS as well as in 90 healthy examination persons,while carotid artery was evaluated by color Doppler ultrasound.Results hs-CRP,Hcy and the carotid artery IMT in PIS groups were the highest,which were significantly higher than non-PIS group and healthy examination group（P0.05）.There was linear regression between the hs-CRP,Hcy and the carotid artery IMT in progressive ischemic stroke groups（r=0.6183,r=0.5862,P0.01）.Conclusion The high levels of hs-CRP and Hcy can increase carotid arteriosclerosis,and promote ischemic stroke progressively.