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Polypill临床研究进展与应用前景 被引量:2

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摘要 Polypill是多种药物组成的同定复方片剂,其优点是能够同时降胆固醇、降血压、减少心血管疾病和卒中风险。因此,它已不同于以往“复方药片”的概念。新近研究均表明由多成分组成的Polypill可降低约60%心血管疾病及40%脑卒中发生率^[1],
作者 姚薇 万征
出处 《中国循证心血管医学杂志》 2012年第6期491-493,共3页 Chinese Journal of Evidence-Based Cardiovascular Medicine
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同被引文献27

  • 1中国成人血脂防治指南制定联合委员会.中国成人血脂异常防治指南[J].中华心血管病杂志,2007,24(3):390-490.
  • 2BUTLER L,SANTORO N. The reproductive endocrinology of the menopausal transition[J]. Steroids,2011,76(7):627-35.
  • 3Yusuf S. Two decades of progress in preventing vascular disease. Lancet, 2002, 360(9326): 2-3.
  • 4Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than 80%. BMI, 2003, 326(7404): 1419.
  • 5Yusuf S, Pais P, Afzal R, et al. Effects of a polypill (Polycap) on risk factors in middle-aged individuals without cardiovascular disease (TIPS) :a phase II, double-blind, randomized trial. Lancet, 2009, 373(9672): 1341-1351.
  • 6de Cates AN, Farr MR, Wright N, et al. Fixed-dose combination therapy for the prevention of cardiovascular disease. Cochrane Database Syst Rev, 2014, 4: CD009868.
  • 7Huffman MD, de Cates AN, Ebrahim S. Fixed-dose combination therapy (polypill) for the prevention of cardiovascular disease. lAMA, 2014, 312(19): 2030-2031.
  • 8Zamorano J, Erdine S, Pavia A, et al. Proactive multiple cardiovascular risk factor management compared with usual care in patients with hypertension and additional risk factors: The CRUCIAL trial. Curr ivied Res Opin, 2011, 27(4): 821-833.
  • 9Thom S, Poulter N, Field J, et al. Effects of a fixed-dose combination strategy on adherence and risk factors in patients with or at high risk of CVD: the UMPIRE randomized clinical trial, lAMA, 2013, 310(9): 918-929.
  • 10Malekzadeh F, Marshall T, Pourshams A, et al. A pilot double-blind randomized placebo-controlled trial of the effects of fixed-dose combination therapy (‘polypfll') on cardiovascular risk factors. Int J Clin Pract, 2010, 64(9): 1220-1227.

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