艾司洛尔和普罗帕酮治疗阵发性室上性心动过速的临床疗效

Curative effect of esmolol and propafenone on paroxysmal supraventricular tachycardia in emergency patients

目的观察艾司洛尔和普罗帕酮治疗阵发室上性心动过速(PSVT)的临床疗效,分析比较两种药物的差异。方法纳入PSVT患者120例,随机分为艾司洛尔组(n=60)和普罗帕酮(n=60)。两组在积极治疗原发病及纠正电解质紊乱、低氧血症,调整盐酸平衡的基础上,艾司洛尔组通过输液泵注射艾司洛尔,初始按负荷量0.5mg/kg,每次增加0.05mg/kg,直至显效,最大剂量≤0.25mg/kg。普罗帕酮组采用注射用水20mL+普罗帕酮70mg缓慢注射(10min～15min)。结果两组治疗有效率无统计学差异(85.0%vs.83.3%,P>0.05),且减慢心率和降低血压的疗效接近(P>0.05)。结论艾司洛尔注射液治疗PSVT与普罗帕酮同等有效。

Objective To analyze the curative effects of esmolol and propafenone on paroxysmal supraventricular tachycardia （ PSVT ） through comparing them. Methods The patients with PSVT （ n =120 ） were randomly divided into esmolol group and propafenone group （ each n =60 ） . On the base of treating original disease, correcting electrolyte disturbance and hypoxemia, and adjusting hydrochloric acid equilibrium in two groups, esmolol group was given injection of esmolol with infusion pump initially according to loading dose （ 0.5 mg/kg ） and adding 0.05 mg/kg at a time until showing effect, and the highest dose being 0.25 mg/kg. Propafenone group was given slow injection of 20 mL water for injection and 70 mg propafenone for 10 minutes to 15 minutes. Results The effective rate had no statistical difference between two groups （ 85.0% vs . 83.3%, P 0.05 ） , and two kinds of medicinal had similar curative effect in slowing heart rate and reducing blood pressure （ P 0.05 ） . Conclusion Esmolol has the same curative effect as propafenone in the treatment of PSVT, and esmolol is quicker and safer.