吸毒人群痰证病理与血清因子等指标的临床研究

CLINICAL RESEARCH ON PHLEGM SYNDROME ANDSERUM FACTORS OF DRUG ADDICTS

目的獉獉:吸毒人群痰证病理与相关血清因子间关系研究。方法獉獉:对吸毒者和健康者进行病例-对照研究,吸毒者诊断标准均符合《中国精神障碍分类与诊断标准》第三版(CCMD-3);中医病理因素采用证素辨证方法采集。结果獉獉:与健康组相比,吸毒组的五脏病位证素积分平均值均显著差异(P<0.01);与健康组相比,吸毒组的痰、湿与气滞和阴虚等病性证素积分平均值均显著差异(P<0.01);痰与5-HT有等级正相关(P<0.05)。结论獉獉:毒品成瘾形成是多脏腑(肝、肾、脾)功能失调的表现,多属虚实夹杂之证。病性主要以痰、湿、气滞、阴虚为主;病位主要在肝、肾。痰证病理产生可能与5-HT指标间存在相关性。

Objective：To investigate the relationship between phlegm syndrome and serum factors of drug addicts.Methods：Case-control method was adopted to study drug addicts and healthy people.Diagnosis standards of drug addicts confirm to the standards in Chinese Classification of Mental Disorders,CCMD-3;The Traditional Chinese medicine（TCM） pathological factors were collected by means of syndrome element differentiation.Results：Compared with the healthy group,the integral means of five zang organs disease focus syndrome element of drug addicts show significant difference（P0.01）;the integral means of disease nature syndrome element,such as phlegm,wet and Qi stagnation and Yin deficiency,of drug addicts show significant difference（P0.01）.There is a positive correlation between sputum and 5-HT（P0.05）.Conclusion：Drug addiction is the result of functional disturbance of several viscera（liver,kidney,spleen）.It can be largely attributed to the intermingled deficiency and excess.The main disease nature is phlegm,wet,Qi stagnation and Yin deficiency;the disease focus mainly lies in liver and kidney.There is a probable relevance between the stubborn phlegm and 5-HT.