群体药代动力学研究进展

Progress in search for population pharmacokinetics

群体药代动力学(PK)用统计学和动力学原理,对不同的人群定量计算其PK参数,并描述其个体间和个体内变异的特征以及来源。近年来其受到越来越多的重视,本文对群体PK的原理及应用进行了综述。

Population pharmacokinetics（PK） , based on the principle of statistics and PK, estimates a given population＇s pharmacokinetic characteristics and their variability, describes the source of inter/intra - individual variability, evaluates the impacts of eovariables, and helps us to understand the in vivo behavior of drug profoundly. There is an increasing focus on the population PK, because of its＇ powerful analysis ability. This article reviewed the principle and application of population PK.