深圳市人群乙肝表面抗体水平及乙肝母婴阻断效果监测分析

Analysis on Hepatitis B Surface Antibody Level and Effect of Blocking HBV Maternal-infant Transmission in Shenzhen

目的了解深圳市人群乙肝表面抗体（HBsAb）水平和接种乙肝疫苗和乙肝免疫球蛋白（HBIG）阻断乙肝母婴传播的效果。方法对〈1岁、1～2岁、3～4岁、5--6岁、7～14岁、15～19岁和≥20岁年龄组人群进行乙肝表面抗体水平监测，对HBsAg阳性母亲所生的7～12月龄儿童进行乙肝母婴阻断效果研究。结果深圳市人群HBsAb阳性率为72．75％，其中小年龄组人群t-IBsAL阳性率较高，≥20岁人群HBsAb阳性率最低；919名HBeAg阳性母亲所生儿童中，HBsAg阳性率为1．41％，HBsAb阳性率为95．21％。结论深圳市人群HBsAb阳性率均高于2006年全国乙肝血清流行病学调查结果，人群抵抗乙肝病毒能力相对较高；乙肝疫苗尤其是乙肝疫苗和乙肝免疫球蛋白联合免疫能有效阻断乙肝母婴传播，分娩方式不会影响乙肝母婴阻断效果。

Objective To investigate the level of hepatitis B surface antibody, the effect of hepatitis B vaccine and HBIG on blocking the maternal - infant transmission. Methods The levels of hepatitis B surface antibody in 〈 1 year, 1 - 2, 3 - 4, 5 6, 7 - 14, 15 - 19 and ≥20 years old population were monitored. The effect of blocking HBV maternal - infant transmission in HBsAg positive mothers＇ infants aged 7 - 12 months was studied. Results The positive rate of ~b was 72.75 %. The positive rates of the younger age groups were higher, while the positive rate of age group ≥20 years was the lowest. Among 919 children with HI,sAg positive mothers, the positive rates of HBsAg and HBsAb were 1.41% and 95.21%, respectively. Conclusions The capacity of against HBV is relatively high in Shenzhen City. Hepatitis B vaccine and HIBG can effectively block HBV maternal- infant transmission, and the delivery mode does not affect the maternal - infant blocking effect.