60μg重组乙型肝炎疫苗(酿酒酵母)对无应答人群免疫效果观察

Observation on Immunological Effect of 60μg Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) on the Non-response Crowd

目的探讨无应答人群接种60μg重组乙型肝炎疫苗(酿酒酵母)免疫成功率和效果。方法选择桃江县40名17岁以上接种常规乙肝疫苗后抗体(抗-HBs)没有阳转的人群,应用深圳康泰生物制品股份有限公司生产的60μg重组乙型肝炎疫苗(酿酒酵母),采用一针接种后1月采血,进行血清免疫学观察。结果接种人群均未出现局部反应和全身反应。接种一针后1个月,阳转率达97.5%,抗-HBs几何平均滴度(GMT)为50.657 mIU/ml。结论 60μg重组乙型肝炎疫苗(酿酒酵母)安全性良好,免疫成功率高,不受地域、年龄组等影响,可以在全国范围内广泛使用,对于常规免疫无应答人群使用60μg/ml乙肝疫苗,免疫效果可能更好。

Objective To explore the immune success rate and effect of 60tag recombinant hepatitis B vaccine （ Saccharornyces cerevisiae） on the HBV vaccine non - response crowd. Methods Forty volunteers aged above 17 years and vaccinated three hepatitis B vaccines for normal dose and procedure but without hepatitis B surface antibody were selected in Taojiang County. The serum samples of the volunteers were collected one month after inoculating one dose of 60μg recombinant hepatitis B vaccine which produced by Shenzhen Kangtai Biological Products Co. Ltd. （SKTB）, and then serum immunological observation was conducted. Results No local reaction and systemic reaction occurred in all volunteers. One month after inoculating one dose of 60μg recombinant hepatitis B vaccine, the positive rate of anti - HBs was 97.5 % and the geometric mean titer for anti - HBs was 50. 657 mIU/ml. Conclusions The results suggest that 60μg recombinant hepatitis B vaccine （ Saccharornyces cerevisiae） has a good safety profile and exerts success in protection. The vaccine is unaffected by region and age, which can be widely applied in the whole country. An excellent immunization efficacy of the vaccine may be found in the HBV vaccine non- response crowd.