抗苗勒氏管激素早期预测卵巢储备功能的研究

Studies of anti-mullerian hormone on early prediction of the ovarian reserve functions

目的:探讨抗苗勒氏管激素(AMH)早期预测卵巢储备功能下降的临床价值及给予相应干预治疗后对其妊娠率的影响。方法:通过检测血清抗苗勒氏管激素,筛查出202例因卵巢储备功能下降导致不孕的患者,随机分为A、B两组,A组未经治疗直接促排卵,B组经人工周期治疗后促排卵,观察两组周期妊娠率、临床妊娠率及B组治疗前后激素水平的变化情况。结果:A组周期妊娠率、临床妊娠率均低于B组,差异均有统计学意义(P<0.05);B组中AMH水平治疗后较治疗前升高,差异有统计学意义(P<0.05)。结论:血清AMH水平可作为临床早期预测卵巢储备功能下降的指标之一;早期诊断卵巢储备功能下降并给予合理的性激素治疗可使卵巢功能得到改善,妊娠率得到提高。

Objective： To explore the clinical value of anti-mullerian hormone in early predicting the decreasing ovarian reserve functions and the effect of pregnancy rate after being treated with homologizing.Methods： 202 patients with decreasing ovarian reserve function were selected by measuring serum levels of anti-mullerian hormone（AMH）,they were divided into two groups randomly.One group（group A） were directly given stimulating ovulation cycles without treatment,the other one（group B） were given stimulating ovulation cycles after artificial menstrual cycle.The difference in cycle and clinic pregnancy rate between the two groups and the hormone level change after the treatment in group B were observed.Results： Cycle and clinic pregnancy rate in group A was lower than group B,there were all significant difference between the two groups（P〈0.05）;Serum levels of AMH after the treatment in group B was higher than that of before the treatment,there is significant difference（P〈0.05）.Conclusion： Serum anti-mullerian hormone may offer scientific proof in early predicting the decreasing ovarian reserve functions.Early diagnosis of decreasing ovarian reserve function and treatment for reasonable sex hormone can ameliorate ovarian functions and improve pregnancy rate.