流行性出血热患者血浆心钠素测定及其意义

DETERMINATION OF PLASMA LEVEL OF CARDIONATRION IN EHF PATIENTS

本文报道用RIA对27例EHF患者血浆ANF测定的结果。资料表明:(1)EHF患者血浆ANF含量(1441.85±898.3pg/ml)明显高于健康人(268.4±86.9pg/ml)(P<0.01)。(2)血浆ANF含量的高低与病情轻重呈平行的关系,即轻型患者虽有增高,但与健康人无明显差异(P>0.05);中型患者增高较显著,重型及危重型患者上升最高,均与健康人有显著性差异(P<0.01)。(3)血浆ANF含量也与病期有一定的关系,即ANF自发热期开始增高,休克期与少尿期达到高峰,多尿期逐渐下降,至恢复期接近正常。(4)有7例急性肾衰患者进行GID治疗后,ANF与ALD、β_2-MG、BUN均较透析前有明显下降(P<0.01)。最后,对EHF患者血浆ANF增高的机理及其临床意义进行了讨论。

Plasma cardionatrion (or atrial natriuretic factor, ANF ) level was deterroined with radioimmunoassay ( RIA ) in 27 patients with epidemic hemorihagic fever ( EHF ) and 50 healthy subjects. The results showed that the average ANF level in EHF patients was much higher thanthat of the healthy subjects ( 1441.85±898. 3pg/ml and 268.4±86 . 9pg/ml respectively, P<0.01). The elevation range of ANF level was found in correlation with the severity and stage of disease. There were significant differences in ANF、ALD、β2-MG、BUN in 7 SHF patients having acute renal failure during pre - and post-GID ( P<0.01 ) . The elevation mechanism in E HF patients and its clinical significance-are briefly discussed.