新生儿乙型肝炎病毒感染情况的研究

A Study on Hepatitis B Virus Infection in Newborns.

【目的】 了解广州市新生儿围产期HBV的感染情况。 【方法】 采用酶联免疫吸附试验 (ELISA)和斑点杂交技术对 2 41例新生儿脐血的乙肝病毒标志物进行检测。 【结果】 广州市新生儿围生期HBsAg阳性率为2 .0 7% (5 /2 41) ,HBsAg阴性、单纯Anti HBc阳性且HBVDNA阳性者 19例 ,占 7.89% (19/2 41) ,新生儿脐血HBV感染率为 9.96 % (2 4/2 41) ,现症HBV感染母亲的新生儿脐血HBV感染率为 72 .73 % (2 4/33) ;母亲与新生儿Anti HBs抗体浓度的相关系数为r =0 .85 ,P =0 .0 0 0 1;新生儿与母亲Anti HBs阳性关联系数为 0 .78,阳性率无差异。 【结论】 现症HBV感染母亲新生儿围产期HBV感染率高 ,以单纯Anti HBs阳性且HBVDNA阳性为主要表现形式 ;母亲Anti HBs阳性者新生儿脐血基本阳性 ,母亲与婴儿Anti

Objective To obtain the infected information of hepatitis B virus (HBV)in newborns. Methods Sera from two hundreds and forty one newborns and their mothers were tested for HBV markers by ELISA and spot hybridization combined with stable group study. Results HBsAg positive rate of newborns was 2.07%(5/241),the cases with HBsAg(-),anti HBc(+) and HBV DNA(+) were 19(19/241,7.89%),the positive rate of babise'naval was 9.96%(24/241);the positive rate of newborns whose mothers were infected with HBV was 72.73%(24.33).The interrelated coefficient of anti HBs concentration between mothers and their babies was 0.85,and that of anti HBc positive rate was 0.78. Conclusions HBV infected rate of newborns whose mothers were patients with HBV infection was high,and the type of HBV infection was mostly anti HBV positive alone;The anti HBc positive rate of pregnant women and that of newborns are almost the same,and anti HBs concentrations of pregnant women and their babies was obvious related.