三氯乙烯药疹样皮炎患者外周血常规及T淋巴细胞亚群变化的观察

Analysis the changes of peripheral blood routine and T lymphocyte subsets of trichloroethyleneinduced medicamentosa-like dermatitis patients

目的了解三氯乙烯药疹样皮炎(TIMLD)病程发展中外周血常规及T淋巴细胞亚群的变化特点,为临床治疗该病提供科学依据。方法检测39例三氯乙烯药疹样皮炎患者不同时期的血常规及T淋巴细胞亚群,并进行统计分析。结果 TIMLD患者发病期间ALT、白细胞计数和中性粒细胞均比恢复期明显升高(P<0.01),但白细胞计数和中性粒细胞与ALT下降趋势不呈比例。而CD3+、CD8+及CD4+/CD8+初期均比中期、恢复期明显升高,而CD4+则降低(P<0.01)。结论三氯乙烯药疹样皮炎外周血常规、T细胞亚群均有异常,值得注意。

Objective To understand the changes of blood routine and T lymphocyte subsets in the course of trichloroethylene- induced medicamentosa-like dermatitis （TIMLD）. Methods Blood routine and T lymphocyte subsets were detected in different times of 39 TIMLD patients. All the data had been processed by statistical analysis. Results Compared with the data of the conva- lescence,the levels of ALT, WBC and neutrophils in the beginning and the mid-term were obviously increased（P〈0.01）. They were decreased but not proportional. The levels of CD3＋ ,CD8＋ and CD4＋/CD8＋ were significantly decreased in the beginning than in the mid-term and the convalescence（P〈0.01） ,but CD4＋ was obviously increased（P〈0.01）. Conclusion Attention should be paid to the abnormal appearance of blood routine and T lymphocyte subsets of TIMLD.