甾体5α-还原酶抑制剂的研究进展

Progress in research of steroidal 5α-reductase inhibitors

前列腺组织内双氢睾酮含量的升高引起良性前列腺增生症 ,而双氢睾酮是通过 5α 还原酶转化睾酮而得 ,因此抑制 5α 还原酶的活性即可达到治疗良性前列腺增生症的目的。本文综述了甾体 5α 还原酶抑制剂的分类。

Benign prostatic hyperplasia(BPH) is resulted from the growth of dihydrotestosterone in the prostate. Studies have demonstrated that human steroidal 5α reductase responsible for the conversion of testosterone into dihydrotestosterone. Thus inhibition of steroidal 5α reductase could offer an alternative therapy for BPH.The classfication,structure activity relationship,and progression in research of 5α reductase inhibitors were reviewed.