IL-1、IL-6、TNF-α、CRP联合检测在维持性血液透析患者微炎症治疗中的临床应用

Clinical application of inflammation factors IL-1,IL-6,TNF-α and CRP united detection in maintenance hemodialysis patients′ during the course of their micro-inflammatory treatment

目的通过联合检测炎症因子白细胞介素1(IL-1)、白细胞介素6(IL-6)、α肿瘤坏死因子(TNF-α)、和C-反应蛋白(CRP),评价维持性血液透析患者治疗前后的微炎症状态。方法选择本院血液净化中心66例慢性肾衰竭患者,随机分两组,A组(对照组)不使用任何血管紧张素受体阻滞剂(ARB)、血管紧张素转换酶抑制剂(ACEI)类药物,B组(实验组)予以口服缬沙坦药物80mg/d,分别测定0月及3月后患者炎症因子IL-1、IL-6、TNF-α、CRP血清水平。结果 B组患者经过3月治疗后IL-1、IL-6、TNF-α、CRP水平降低(P<0.05),A组CRP、IL-1、IL-6水平升高(P<0.05),TNF-α水平升高不明显(P>0.05);Pearson相关性分析结果显示患者治疗后的IL-1、IL-6、TNF-α、CRP水平呈正相关。结论炎症因子IL-1、IL-6、TNF-α、CRP的联合检测可正确反映缬沙坦对维持性血液透析患者微炎症的治疗效果。

Objective To evaluate maintenance hemodialysis patients′ micro-inflammatory state by united detecting inflammation factors IL-1,IL-6,TNF-α and CRP.Methods Sixty-six patients with chronic renal failure who were treated with maintenance hemodialysis over or for three months in our blood purification center were selected.They were randomly divided into two groups.Group A didn′t use any ARB,ACE-I drugs,Group B were selected to receive valsartan 80 mg/d for three months.The serum level of maintenance hemodialysis patients′ Inflammation factors IL-1,IL-6,TNF-α and CRP before treatment and after three monthstreatment were detected.Results After treatment for three months,the group B patients′ inflammation factors were significantly reduced（P0.05）,and the group A patients′ inflammation factors were increased（P0.05）,but the serum level of TNF-α increased unobviously（P0.05）.Pearson analysis revealed that the micro-inflammatory state had a positive correlation with the level of the IL-1,IL-6,TNF-α,CRP in maintenance hemodialysis patients after treatment.Conclusion The united detection results of serum level the IL-1,IL-6,TNF-α and CRP may reflect the treatment effectiveness of valsartan for maintenance hemodialysis patients′ micro-inflammatory correctly.