抗敏一号方治疗青少年及成人期特应性皮炎疗效观察

Effect of Antiallergic Recipe Ⅰ on Atopic Dermatitis in Adolescent and Adult

目的从皮损范围、皮损严重程度以及瘙痒、睡眠对患者的影响程度等方面,通过对照研究,观察抗敏一号方对青少年及成人期特应性皮炎的临床疗效,为进一步研究中医药治疗特应性皮炎的方法提供依据。方法将符合纳入标准的64例门诊患者,按队列研究的方法分为治疗组32例和对照组32例,治疗组运用抗敏一号方,对照组予以开瑞坦治疗,2组同时外涂樟脑霜。疗程为4周。每例分别观察治疗前和治疗后患者的皮损范围、严重程度及瘙痒和睡眠对患者的影响程度,分别进行量化评分,观察疗效。结果治疗组和对照组治疗前量化积分、年龄、病程差异均无统计学意义(P>0.05),治疗前后2组在皮损范围、皮损严重程度及瘙痒和睡眠影响度的症状改善上差异均有统计学意义(P<0.05),其有效率分别为78.13%和46.88%;治疗组的疗效及对皮损范围、皮损严重度的改善与对照组疗效比较差异具有统计学意义(P<0.001),而在瘙痒和睡眠的改善方面,2组差异无统计学意义(P>0.05)。结论运用抗敏一号方和开瑞坦治疗青少年及成人期特应性皮炎具有一定的临床疗效;抗敏一号方对皮损范围、皮损严重度的改善优于开瑞坦,值得进一步研究推广。

Objective To assess the clinical effect of antiallergic recipe Ⅰ on atopic dermatitis （AD） in adolescent and adult and to provide evidence for further application of traditional Chinese medicine （TCM） on AD. Methods 64 eligible out-patients were randomly assigned into two groups： treatment group （n=32） and control group （n=32）. Patients in treatment group were treated with antiallergic recipe Ⅰ , while patients in control group were treated with Clarityne. All patients were co-administered with camphor cream. Each patient was treated for four weeks. Lesion size, severity, pruritus and impact on sleeping of pre- and post-treat were recorded and graded. Results No significant difference was observed in pre-treatment score, age, duration of disease （P〉0.05）. In both two groups, there was significant difference in lesion size, severity, pruritus and impact on sleeping following treatment compared with pre-treatment, with respective effective rate of 78.13% （treatment group） and 46.88% （control group） （P〈0.05）. In lesion size and severity, antiallergic recipe Ⅰ was significant superior to Clarityne （P〈0.001）, while in pruritus and impact on sleeping, no significant difference was observed （P〉0.05）. Conclusion Antiallergic recipe Ⅰ and Clarityne are effective on atopic dermatitis in adolescent and adult. Antiallergie recipe Ⅰ is superior to Clarityne in lesion size and severity and worthy further development.