中药对干细胞移植治疗骨关节炎的干预效应

Interventional effects of traditional Chinese medicine in the treatment of osteoarthritis by stem cells transplantation

背景:干细胞具有分化成软骨细胞的特性,应用干细胞移植治疗骨关节炎已在大量的动物实验中证实,而临床应用才刚开始。目的:对中药干预干细胞移植治疗骨关节炎的研究现状及新进展作一综述。方法:应用计算机检索CNKI和Pubmed数据库中1997年1月至2011年12月关于中药对干细胞作用及干细胞移植治疗骨关节炎的文章,在标题和摘要中以"中药、骨关节炎、干细胞、移植"或"traditional Chinese medicine、osteoarthritis、stem cell、transplantation"为检索词进行检索。选择相关文献,根据入选标准对纳入的32篇文献进行综述。结果与结论:随着中药现代化进程,根据中医相关理论,研究发现应用中药可促进骨关节炎软骨细胞增殖,并能促进干细胞的增殖及向软骨细胞分化和代谢,有利于缺损软骨的修复。但现阶段的研究力度仍不足,今后应加强中药干预干细胞的基础研究,在干细胞增殖、分化及转分化机制研究基础上,有针对性地筛选能调节干细胞不同发育阶段的的中药单体或复方。

BACKGROUND： Stem cells have the characteristics that can differentiate into chondrocytes. Stem cell transplantation for the treatment of osteoarthritis has been confirmed in a large number of animal experiments, and the clinical application is just beginning. OBJECTIVE： To investigate the interventional effects of traditional Chinese medicine in the treatment of osteoarthritis by stem cells transplantation. METHODS： The CNKI database and PubMed database （1997 01/2011 12） were used to search the articles about the effect of traditional Chinese medicine in the treatment of osteoarthritis by stem cells transplantation. The key words are ＂traditional Chinese medicine, osteoarthritis, stem cell and transplantation＂. Then 32 articles were included for review. RESULTS AND CONCLUSION： With the modernization of traditional Chinese medicine, according to traditional Chinese medicine theory, studies have shown that traditional Chinese medicine application for osteoarthritis can promote the proliferation of chondrocytes, accelerate the differentiation of stem cells into chondrocytes, and facilitate the repair of cartilage defects. But the researches at the present stage are inadequate, so the basic research regarding the interventional effects of traditional Chinese medicine on stem cells should be strengthened in the future. On the basis of stem cell proliferation, differentiation and trans-differentiation mechanism, we should screen the Chinese medicine monomer or compound that can interfere the stem cells at different developmental stages.