中药被动靶向制剂的研究进展

Advances on the research of passive targeting preparation for traditional Chinese medicine

中药被动靶向制剂(passive targeting preparation)是利用药物载体(drug carrier)将中药制成脂质体、乳剂、微球、纳米粒等,进入体内被巨噬细胞作为外界异物吞噬后,选择性地浓集于靶组织(肝脏、淋巴组织、肿瘤细胞等)释放药物,发挥疗效。目前,对脂质体、乳剂、微球、纳米粒的组成、特点、作用机制和应用现状等方面的研究取得了一些进展,研究显示,中药被动靶向制剂作为一类新型靶向药物是今后中医药发展的重要课题。

The article summarizes the advance of passive targeting preparation for traditional Chinese medicine. The document of relevant materi- als of passive targeting preparation is consulted. Passive Targeting preparation for traditional Chinese traditonal drug is liposome, emulsions, mi- crospheres, nanopartilcles made from drug carrier, devoured by phagocyte. Medication is released and produce therapeutic effect in the targeting tissues （ liver, lymph, tumor cell, et al） selectively. This paper summarizes the research advance on classification, characters, mechanism and ap- plication of passive targeting preparation for traditional Chinese medicine. As a new - style targeted drug, passive targeting preparation for tradi- tional Chinese medicine is important task for the development on traditional Chinese medicine