中医治疗尖锐湿疣用药规律分析

Analysis on the Rule of Medication of Traditional Chinese Medicine for the Treatment of Verruca Acuminata

目的:通过对治疗尖锐湿疣所用中药进行回顾性整理分析,寻找中医治疗尖锐湿疣的用药规律。方法:对1979年6月至2012年6月中国期刊全文数据库(源于CNKI)收录的用中医、中西医结合治疗尖锐湿疣的文献,以《中药学》和《中药大辞典》使用术语为标准进行收集整理,应用SPSS 17.0对药物频率分布进行统计分析。结果:按照标准检索到文献331篇,涉及中药254味,频次3 729次,所用药物按照《中药学》分类整理为43类,进一步将药物功效合并为20大类,使用频次大于1%的药物依次是板蓝根、苦参、黄柏、薏苡仁、土茯苓、大青叶、马齿苋、紫草、甘草、白矾、蛇床子、木贼、红花、黄芪、莪术、香附、龙胆、金银花、白花蛇舌草、桃仁、苍术、蒲公英、地肤子、虎杖、当归、白术、大黄、白鲜皮、赤芍、蜂房、百部、黄芩、鸦胆子,一些单味药如鸦胆子、八角莲、黄药子等对本病具有独特疗效。外用以清热药、攻毒杀虫止痒药为主,内服以清热药、补益药、利水渗湿药、活血化瘀药为主。外用与内服药间有一定区别,χ2分析两组间攻毒杀虫止痒药、解表药、泻下药、收涩药、温里药、开窍药,差异有统计学意义(P<0.01)。结论:近30 a治疗尖锐湿疣中医内服、外治用药有各自优势,尖锐湿疣主要相关病理因素是热、毒、湿、虚、瘀。

Objective： To explore the rules of medication through retrospective analysis of traditional Chinese medicine treatment for verruca acuminata.Methods： Chinese drugs appeared in the literatures of traditional Chinese medicine,combined with Chinese and western medicine treatment for verruca acuminata were selected by CNKI from June 1979 to June 2012,and the terms used in＂Chinese Medicine＂and＂Chinese Medicine dictionary＂as the standard were collected and sorted out.Drugs frequency distribution was statistically analyzed by SPSS 17.0.Results： 331 literatures were searched according to the standard,and 254 species of Chinese medicine were involved,with the total frequency of 3 729 times.The drugs used were classified into 43 categories and were further incorporated into 20 total categories by functions.The Chinese drugs whose percentage exceeded 1% was Radix Isatidis,Radix Sophorae Flavescentis,Cortex Phellodendri Chinensis,Semen Coicis,Rhizoma Smilacis Glabrae,Folium Isatidis,Herba Portulacae,Radix Arnebiae,Radix Glycyrrhizae,Alumen,Fructus Cnidii,Herba Equiseti Hiemalis,Flos Carthami,Astragalus root,Rhizoma Curcumae,Rhizoma Cyperi,radix geutianae,Flos Lonicerae Japonicae,Hedyotic Diffusa,Semen Persicae,Rhizoma Atractylodis,Herba taraxaci,Fructus Kochiae,Polygonum cuspidatum,Radix Angelicae Sinensis,atractylis ovata,Chinese rhubarb,Cortex Dictamni,Radix Paeoniae Rubra,Nidus Vespae,Radix Stemonae,Radix Scutellariae,Brucea javanica.Some single Chinese drugs,for example Brucea javanica,Dysosma,Rhizoma Dioscoreae Bulbiferae had peculiar effectiveness in treating the disease.Drugs for clearing heat and eliminating virus or insect to alleviate itching were most used externally.Drugs for clearing pathogenic heat,deficiency-nourishing drugs,drugs for inducing diuresis and removing dampness,drugs for promoting blood circulation to eliminate stasis were mainly for oral administration.Medicines for both internal and external use had some difference,and the differences between the two groups in eliminating virus or insect to alleviating itching drugs,drugs for relieving exterior syndrome,purgating drugs,astringent medicine,interior-warming drugs,awaking drugs by chi-square analysis were statistical significant（P〈0.01）.Conclusion： Drugs for oral administration and external use in TCM treatment for verruca acuminata have their respective advantages for nearly 30 years,and the main pathological factors of verruca acuminata were heat,poison,humidity,deficiency and blood stasis.