活血化瘀法调控骨髓间充质干细胞旁分泌促血管再生研究述评

Research Progress of Medicinal Herbs for Blood-activating and Stasis-dissolving Regulation of Bone Marrow Mesenchymal Stem Cells Paracrine for Promoting Revascularization

目的:探讨活血化瘀中药调控骨髓间充质干细胞旁分泌促血管再生的作用机制。方法:总结近年来关于血管再生研究现状,从中医"生新"等理论出发,分析活血化瘀中药促进血管再生的机制。结果:根据前期的研究基础,认为活血化瘀中药可促进血管再生,并提出了研究思路和方法以及探讨其作用机制的指标。结论:活血化瘀中药通过调控骨髓间充质干细胞旁分泌可促进血管再生。

Objective： To explore the research mechanisms of medicinal herbs for blood-activating and stasis-dissolving regulation of bone marrow mesenchymal stem cells paracrine for promoting revascularization.Methods： Research status of revascularization was summarized,and the mechanism of medical herbs for blood-activating and stasis-dissolving for promoting revascularization was analyzed from theTCM theory of＂producing new blood＂to start.Results： Medicinal herbs for blood-activating and stasis-dissolving were considered to promote revascularization based on research foundations in early stage,and the research thinkings,methods and indexes to study its mechanisms were proposed.Conclusion： Medicinal herbs for blood-activating and stasis-dissolving can promote revascularization through regulation of bone marrow mesenchymal stem cells paracrine.