期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

脑源性神经营养因子与抑郁症的研究进展 被引量：3

原文传递
导出
摘要 抑郁症以其高患病率、高复发率、高致残率和高致死率的特点，近年来成为精神疾病的第一号杀手。根据世界卫生组织发表的《2002年世界卫生报告》，抑郁症已成为世界第四大疾患，到2020年，抑郁症可能成为仅次于心脏病的第二大疾病。抑郁症对人类的危害已越来越引起社会的关注，有关抑郁症病因及发病机制的研究也层出不穷。“神经营养假说”的提出为抑郁症的病因研究开拓了新的思路，
作者 冯玉 杨志寅 吉峰
机构地区 新乡医学院 济宁医学院
出处 《中华行为医学与脑科学杂志》 CAS CSCD 北大核心 2013年第1期84-86,共3页 Chinese Journal of Behavioral Medicine and Brain Science
基金 基金项目：山东省自然科学基金项目（ZR2010CM031）
关键词 脑源性神经营养因子 抑郁症 《2002年世界卫生报告》 世界卫生组织 精神疾病 高复发率 发病机制 患病率
分类号 R74 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献36

  • 1Cattaneo A,Bocchio-Chiavetto L,Zanardini R. Reduced peripheral brain-derived neurotrophic factor mRNA levels are normalized by antidepressant treatment[J].International Journal of Neuropsychopharmacology,2010.103-108.
  • 2Brunoni AR,Lopes M,Fregni F. A systematic review and meta-analysis of clinical studies on major depression and BDNF levels:Implications for the role of neuroplasticity in depression[J].International Journal of Neuropsychopharmacology,2008.1169-1180.
  • 3Martinowich K,Manji H,Lu B. New insights into BDNF function in depression and anxiety[J].Nature Neuroscience,2007,(9):1089-1093.doi:10.1038/nn1971.
  • 4Ibarguen-Vargas Y,Surget A,Vourch P. Deficit in BDNF does not increase vulnerability to stress but dampens antidepressant-like effects in the unpredictable chronic mild stress[J].Behavioural Brain Research,2009.245-251.
  • 5Numakawa T,Suzuki S,Kumamaru E. BDNF function and intracellular signaling in neurons[J].Histology and Histopathology,2010.237-258.
  • 6Martinowich K,Manji H,Lu B. New insights into BDNF function in depression and anxiety[J].Nature Neuroscience,2007,(9):1089-1093.doi:10.1038/nn1971.
  • 7Yoshida T,Ishikawa M. Decreased serum levels of mature brain-derived neurotrophic factor(BDNF),but not its precursor proBDNF,in patients with major depressive disorder[J].PLoS ONE,2012.e42676.
  • 8Hiroshi K,Hiroaki H. Interface between hypothalamic-pituitary-adrshal axis and brain-derived neurotrophic factor in depression[J].Psychiatry and Clinical Neurosciences,2010.447-459.
  • 9David DJ,Samuels BA,Rainer Q. Neurogenesis-dependent and-independent effects of fluoxetine in an animal model of anxiety/depression[J].Neuron,2009.479-493.
  • 10Taliaz D,Stall N,Dar DE. Knockdown of brain-derived neurotrophic factor in specific brain sites precipitates behaviors associated with depression and reduces neurogenesis[J].Molecular Psychiatry,2010,(1):80-92.doi:10.1038/mp.2009.67.

二级参考文献30

  • 1Kornstein SG, Schatzberg AF, Thase ME, et al. Gender differences in treatment response to sertraline versus imipramine in chronic depression. Am J Psychiatry,2000,157 : 1445-1452.
  • 2Scheibe S,Preuschhof C, Crlsti C, et al. Are there gender differences in major depression and its response to antidepressants? J Affect Disord,2003,75:223-235.
  • 3Mulder RT,Watkins WG,Joyce PR,et al. Age may affect response to antidepressants with serotonergic and noradrenergie actions. J Affect Disord ,2003,76 : 143-149.
  • 4Kilts CD,Wade AG, Andersen HF,et al. Baseline severity of depression predicts antidepressant drug response relative to escitalopram. Expert Opin Pharmacother,2009,10:927-936.
  • 5Kaplan M J, Klinetob NA. Childhood emotional trauma and chronic posttraumatic stress disorder in adult outpatients with treatment-resistant depression. J Nerv Ment Dis,2000,188:596-601.
  • 6Nemeroff CB, Heim CM, Thase ME, et al. Differential responses to psychotherapy versus pharmacotherapy in patients with chronic forms of major depression and childhood trauma. Proc Natl Acad Sci USA, 2003,100 : 14293-14296.
  • 7Weissman MM, Bland R,Joyce PR,et al. Sex differences in rates of depression : cross-national perspectives. J Affect Disord, 1993,29 : 77- 84.
  • 8Little A. Treatment-resistant depression. Am Faro Physician, 2009, 80 : 167-172.
  • 9Kohn Y,Zislin J, Agid O,et al. Increased prevalence of negative life events in subtypes of major depressive disorder. Compr Psychiatry, 2001,42:57-63.
  • 10American Psychiatry Association. Diagnostic and statistical manual of mental disorders. 4th ed. Washington DC : APA, 1994:256-258.

共引文献8

同被引文献35

  • 1Kessler RC, Berglund P, Demler O, et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comor- bidity Survey Replication. Arch Gen Psychiatry,2005,62:593-602.
  • 2King AC, Taylor CB, Haskel! WL. Effects of differing intensities and formats of 12 months of exercise training on psychological outcomes in older adults. Health Psychol,1993 ,12 :292-300.
  • 3DiLorenzo TM, Bargman EP, Stucky-Ropp R, et al. Long-term effects of aerobic exercise on psychological outcomes. Prey Med, 1999,28 : 75 -85.
  • 4Dunn AL,Trivedi MH, Kampert JB, et al. Exercise treatment for de- pression: efficacy and dose response. Am J Prev Med,2005,28:1-8.
  • 5Blumenthal JA, Babyak MA, Moore KA, et al. Effects of exercise training on older patients with major depression. Arch Intern Med, 1999,159:2349-2356.
  • 6Singh NA, Stavrinos TM, Scarbek Y, et al. A randomized controlled trial of high versus low intensity weight training versus general practi- tioner care for clinical depression in older adults. J Gerontol A Biol Sci Med Sci ,2005,60:768-776.
  • 7Struder HK, Weicker H. Physiology and pathophysiology of the sero- tonergic system and its implications on mental and physical perform- ance. Part II. Int J Sports Med,2001,22 :482-497.
  • 8Ernst C, Olson AK, Pinel JP, et al. Antidepressant effects of exercise : evidence for an adult-neurugenesis hypothesis.? J Psychiatry Neurosci, 2006,31:84-92.
  • 9Thoren P, Floras JS, Hoffmann P, et al. Endorphins and exercise: physiologieal mechanisms and clinical implieations. Med Sci Sports Exerc, 1990,22:417-428.
  • 10Farrell PA, Gates WK, Maksud MG, et al. Increases in plasma beta- endorphin/beta-lipotropin immunoreaetivity after treadmill running in humans. J Appl Physiol, 1982,52 : 1245-1249.

引证文献3

二级引证文献32

中华行为医学与脑科学杂志
2013年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部