文拉法辛合并喹硫平治疗难治性抑郁症临床观察

Effect venlafaxine combined with quetiapine of in the treatment of refractory depression

目的:观察文拉法辛联合喹硫平对难治性抑郁症治疗的疗效和不良反应,探讨难治性抑郁症的治疗方案。方法:对符合难治性抑郁症患者95例,随机分组为研究组(文拉法辛合并喹硫平)和对照组(单用文拉法辛),治疗8周,使用HAMD和HAMA量表评定疗效,第2、4、6、8周末进行评分,比较观察疗效,使用TESS量表评定不良反应。结果:研究组疗效显著优于对照组,其HAMD、HAMA量表评分减分率,疗效评定均优于对照组,不良反应无显著性差异。结论:文拉法辛联用喹硫平对难治性抑郁症有较好的疗效,可提高近期临床疗效。

OBJECTIIE To explore the efficacy and adverse effects of venlafaxine combined with quetiapine in the treatment of refractory depression, and to investigate the treatment regime of refractory depression. METHODS 95 patients who met the diagnostic criteria for refractory depression were randomly divided into two groups. The research group （n = 49） received ven- lafaxine combined with quetiapine and the control group （n = 46） received venlafaxine for 6 weeks. Clinical efficacy and adverse reactions were assessed with the Hanmilton depression scale （HAMD）, Hamilton Anxiety Scale （HAMA） and Treatment emergent symptomscale （TESS） at 2,4,6,8 weeks after treatment. RESULTS The research group had better efficacy than the control group by comparing the scores of HAMD and HAMA. There was no difference in the incidence of adverse reactions between the two groups. CONCLUSION Venlafaxine combined with quetiapine in the treatment of refractory depression has better efficacy, it could improve the recent clinical efficacy.