生物相容壳聚糖/蒙脱土复合微球的溶胀与药物缓释性能研究

Study on swelling and drug release properties of biocompatible chitosan/montmorillonite composite microspheres

利用反相乳液聚合法制备出具有良好生物相容性的壳聚糖/蒙脱土复合微球,其中改性蒙脱土作为插层改性剂引入。用X射线衍射和红外光谱分析了改性蒙脱土的结构,以阿司匹林为模型药物,以药物包埋法制备出了壳聚糖/蒙脱土载药微球,并对其缓释性能进行探讨。结果表明,改性蒙脱土的层间距变大,随着蒙脱土含量的增大,复合微球的溶胀率降低,释药率逐渐减小,pH值为1.2下的壳聚糖/蒙脱土载药微球的释药模式为Fickian扩散类型,pH值为7.4下的释药模式为non-Fickian扩散,壳聚糖/蒙脱土复合微球作为药物载体很有潜力。

Chitosan/montmorillonite composite microspheres with good biocompatibility were prepared by in- verse emulsion polymerization, and modified montmorillonite was introduced as intercalation modifier. The structure of modified montmorillonite was analyzed by X-ray diffraction and infrared spectroscopy. Drug-loaded chitosan/montmorillonite microspheres were prepared with aspirin as the model drug by drug entrapment meth- od and drug release properties were discussed. The results are as follows. The interlayer distance of modified montmorillonite becomes larger. The swelling rate and drug release rate of composite microspheres reduces with the content of montmorillonite increasing. The release mode of drug-loaded chitosan/montmorillonite mi- crospheres is Fickian diffusion type at pill. 2. The release mode is non-Fickian diffusion type at pHT. 4. Chi tosan/montmorillonite composite microspheres have great potential as a drug carrier.