孕激素相关子宫内膜蛋白基因与肿瘤

Progestagen-associated endometrial protein gene and tumor

孕激素相关子宫内膜蛋白（PAEP）基因是一个主要表达于分泌期子宫内膜和妊娠早期蜕膜的基因。近年来研究表明，PAEP基因在乳腺癌、子宫内膜癌、卵巢癌、胃癌、恶性黑素瘤等多种肿瘤组织中表达上调，对肿瘤发生发展起重要作用。要将PAEP基因作为临床诊断、预后判断及指导治疗的指标，还需进一步研究PAEP基因对肿瘤生物学行为影响的作用机制。

Progestagen-associated endometrial protein （PAEP） gene mainly expresses in the secretory. phase endometrium and decidua in early trimester of pregnancy. In recent years, it is reported that PAEP is abnormally expressed in many kinds of tumors, such as breast cancer, endometrial carcinoma, ovary cancer, stomach cancer and melanoma. PAEP gene plays an important role in tumorigenesis and tumor development. The application of PAEP gene as an indicator for clinical diagnosis, prognostic and therapy needs further studies on the influence of PAEP gene on tumor biological behaviour.