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结肠癌转移相关基因1与肿瘤 被引量：1

Metastasis-associated in colon cancer-1 and tumor
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摘要 结肠癌转移相关基因1（MACC1）为新近发现的调节肿瘤生长和转移的基因，在多种恶性肿瘤中异常表达，其编码蛋白作为HGF-MET信号通路的一个关键调节因子，可明显增强肿瘤细胞的侵袭及转移能力。 Metastasis-associated in colon cancer-1 （ MACC1 ）, a newly discovered geue which controls tumor growth and metastasis, abnormally expresses in a variety of malignant tumors. As a key regulator of HGF-MET signal pathway, its coding protein can obviously promote invasion and metastasis of tumor ceils.
作者 李祯 生秀杰
机构地区 广州医学院第三附属医院妇产科研究所广东省普通高校生殖与遗传重点实验室
出处 《国际肿瘤学杂志》 CAS 2013年第1期15-18,共4页 Journal of International Oncology
关键词 结肠癌转移相关基因1 肿瘤 肿瘤转移 Metastasis-associated in colon cancer-I Neoplasms Neoplasm metastasis
分类号 R737.33 [医药卫生—肿瘤]
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参考文献5

二级参考文献80

  • 1Stein U,Walther W,Arlt F,et al.MACC1,a newly identified key regulator of HGF-MET signaling,predicts colon cancer metastasis[J].Nat Med,2009,15(1):59-67.
  • 2Rygaard K,Nakamura T,Spang-Thomsen M,et al.Expression of the proto-oncogenes c-met and c-kit and their ligands,hepatocyte growth factor/scatter factor and stem cell factor,in SCLC cell lines and xenografts[J].Br J Cancer,1993,67(1):37-46.
  • 3Gautam Maulik,Takashi Kijima,Patrick C Ma,et al.Modulation of the c-Met/hepatocyte growth factor pathway in small cell lung cancer[J].Clin Cancer Res,2002,8(2):620-627.
  • 4Jeffers M,Rong S,Vande Woude GF.Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-met signalling in human cells concomitant with induction of the urokinase proteolysis network[J].Mol Cell Biol,1996,16(3):1115-1125.
  • 5Jeffers M,Rong S,Woude GF.Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and invasion/metastasis[J].J Mol Med,1996,74(9):505-513.
  • 6Shirahata A,Sakata M,Kitamura Y,et al.MACC1 as a marker for peritoneal-disseminated gastric carcinoma[J].Anticancer Res,2010,30(9):3441-3444.
  • 7Shirahata A,Sakata M,Kitamura Y,et al.MACC1 as a marker for advanced colorectal carcinoma[J].Anticancer Res,2010,30(7):2689-2692.
  • 8Katarzyna Kokoszyńska1,Jacek Kryński,Leszek Rychlewski,et al.Unexpected domain composition of MACC1 links MET signaling and apoptosis[J].Acta Biochim Pol,2009,56 (2):317-323.
  • 9Stein U,Dahlmann M,Walther W,et al.MACC1-more than metastasis? Facts and predictions about a novel gene[J].J Mol Med,2010,88(1):11-18.
  • 10Birchmeier C,Birchmeier W,Gherardi E,et al.Met,metastasis,motility and more[J].Nat Rev Mol Cell Biol,2003,4(12):915-925.

共引文献66

同被引文献28

  • 1Gavin PG,Colangelo LH,Fumagalli D,et al.Mutation profiling and microsatellite instability in stage Ⅱ and Ⅲ colon cancer:an assessment of their prognostic and oxaliplatin predictive value[J].Clin Cancer Res,2012,18(23):6531-6541.
  • 2Lagarde P,Pérot G,Kauffmann A,et al.Mitotic checkpoints and chromosome instability are strong predictors of clinical outcome in gastrointestinal stromal tumors[J].Clin Cancer Res,2012,18 (3):826-838.
  • 3Shull AY,Clendenning ML,Ghoshal-Gupta S,et al.Somatic mutations,allele loss,and DNA methylation of the Cub and Sushi Multiple Domains 1 (CSMD1) gene reveals association with early age of diagnosis in colorectal cancer patients[J].PLoS One,2013,8 (3):e58731.
  • 4Pagin A,Zerimech F,Leclerc J,et al.Evaluation of a new panel of six mononucleotide repeat markers for the detection of DNA mismatch repair-deficient tumours[J].Br J Cancer,2013,108 (10):2079-2087.
  • 5Sinicrope FA,Sargent DJ.Molecular pathways:microsatellite instability in colorectal cancer:prognostic,predictive,and therapeutic implications[J].Clin Cancer Res,2012,18 (6):1506-1512.
  • 6Pinheiro M,Ahlquist T,Danielsen SA,et al.Colorectal carcinomas with microsatellite instability display a different pattern of target gene mutations according to large bowel site of origin[J].BMC Cancer,2010,10:587-596.
  • 7Chen W,Yuan L,Cai Y,et al.Identification of chromosomal copy number variations and novel candidate loci in hereditary nonpolyposis colorectal cancer with mismatch repair proficiency[J].Genomics,2013,102(1):27-34.
  • 8Fournier A,Sasai N,Nakao M,et al.The role of methyl-binding proteins in chromatin organization and epigenome maintenance[J].Brief Funct Genomics,2012,11 (3):251-264.
  • 9Walton EL,Francastel C,Velasco G.Maintenance of DNA methylation:Dnmt3b joins the dance[J].Epigenetics,2011,6 (11):1373-1377.
  • 10Bae JM,Kim JH,Cho NY,et al.Prognostic implication of the CpG island methylator phenotype in colorectal cancers depends on tumour location[J].Br J Cancer,2013,109(4):1004-1012.

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国际肿瘤学杂志
2013年 第1期

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