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CD44在肿瘤进展中的作用 被引量：1

Effects of CD44 in cancer progression
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摘要 CD44在生理过程及肿瘤中的作用一直是研究的热点，通过与不同配体结合，可激活一系列级联反应，不仅可以促进肿瘤形成和转移，还可以抑制肿瘤生长和进展。深入研究CD44及其在信号通路中的作用，可为肿瘤治疗提供新途径。 CD44 has been the subject of extensive research because of its role in cancer and many physiological processes. Through binding to different ligands, CD44 can initiate a series of cascade. CD44 not rally can promote tumorigenic and tumor metastasis, but also can suppress tumor growth and progression. In-depth study of CD44 and its role in signal pathway may provide a new path for cancer treatment.
作者 李丹华 张斌 曹旭晨
机构地区 天津医科大学附属肿瘤医院乳腺一科乳腺癌防治教育部重点实验室天津市肿瘤防治重点实验室
出处 《国际肿瘤学杂志》 CAS 2013年第1期18-21,共4页 Journal of International Oncology
基金 国家自然科学基金（81001186） 天津市自然科学基金（10JCYBJC14100,11JCZDJC28000）
关键词 CD44 肿瘤转移 预后 CD44 Neoplasm metastasis Prognosis
分类号 R73-3 [医药卫生—肿瘤]
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参考文献23

  • 1Negi LM,Talegaonkar S,Jaggi M. Role of CD44 in tumour progression and strategies for targeting[J].Journal of Drug Targeting,2012,(07):561-573.
  • 2Zoller M. CD44:can a cancer-initiating cell profit from an abundantly expressed molecule[J].Nature Reviews Cancer,2011,(04):254-267.
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同被引文献7

  • 1盛亚琳.细胞粘附分子CD44与肿瘤关系的研究进展[J].实用医技杂志,2008,15(7):926-928. 被引量：5
  • 2田文,张国华,谷志远,宋海静,赵亚力.CD44异常表达与结肠直肠癌形成和转移的关系[J].中华医学杂志,1997,77(8):631-634. 被引量：10
  • 3Katapodi MC,Northouse LI,Schafenacker AM,et al.Using a state cancer registry to recruit young breast cancer survivors and high-risk relatives:protocol of a randomized trial testing the efficacy of a targeted versus a tailored intervention to increase breast cancer screening[J].BMC Cancer,2013,13(1):97.
  • 4Heider KH,Kuthan H,Stehle C,et al.CD44v6:a target for antibody-based cancer therapy[J].Cancer Immunol Immunother,2004,53:567-579.
  • 5Afify A,Purnell P,Nguyen L.Role of CD44sand CD44v6on human breast cancer cell adhesion,migration,and invasion[J].Exp Mol Pathol,2009,86(2):95-100.
  • 6Nicolson GL.Organ specificity of tumor metastasis:role of preferential adhesion,invasion and growth of malignant cells at specific secondary sites[J].Cancer Metastasis Rev,1988,7(2):143-188.
  • 7焦路阳,郭庆合,鲁广建.血清TSGF、CA153、CA125、CEA联合检测在乳腺癌诊断中的应用[J].现代预防医学,2012,39(18):4692-4693. 被引量：14

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国际肿瘤学杂志
2013年 第1期

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