支气管动脉介入治疗与静脉化疗中晚期肺癌的疗效分析

Bronchial artery interventional therapy and intravenous chemotherapy in advanced lung cancer curative effect analysis

目的通过分析支气管动脉介入治疗与静脉化疗中晚期肺癌的近期疗效，探讨其最佳治疗方法。方法回顾性分析2008年1月至2011年3月接受治疗的中晚期肺癌患者75例，其中支气管动脉介入42例，静脉化疗33例；介入治疗患者中行支气管动脉化疗加栓塞29例，支气管动脉化疗13例。分析2种治疗方法与肺癌类型之间及不同介入治疗方法之间与疗效的关系。结果支气管动脉介入治疗中央型、多血供型、非小细胞型肺癌疗效明显优于静脉化疗（P〈O．01），而周围型、乏血供型、小细胞型肺癌两种治疗方法疗效比较差异无统计学意义（P〉0．05）；支气管动脉化疗加栓塞疗效明显优于支气管动脉化疗（P〈O．05）。结论支气管动脉介入和静脉化疗的疗效与肺癌的类型有关，根据肺癌类型的发病特点，认为支气管动脉介入是治疗中晚期肺癌的重要手段之一，如无栓塞禁忌证应首选支气管动脉化疗加栓塞。

Objective To explore the best treatment method through analyzing short-term curative effect of bronchial artery interventional therapy and intravenous chemotherapy in advanced lung cancer. Methods The data of 75 cases of advanced lung cancer were retrospectivly analyzed, among whom 42 cases received bronchial artery intervention, 33 cases received intravenous chemotherapy. In patients with interventional therapy, 29 cases received bronchial arterial chemotherapy and embolization, 13 cases received bronchial arterial chemotherapy. The relationships between two kinds of treatment methods and the types of lung cancer and between the different intervention methods and curative effect were analyzed. Results The curative effect of bronchial artery intervention was superior to that of intravenous chemotherapy in central type, multi-blood supply, and non-small cell lung cancer （ P 〈C0.01）. There was no significant difference on curative effect between bronchial artery intervention and intravenous chemotherapy in peripheral type, lack of blood supply, and small cell lung cancer （ P 〉0.05）. The therapeutic effect of bronchial arterial chemotherapy and embolization was superior to that of bronchial artery chemotherapy （ P 〈0.05）. Conclusions The therapeutic effect of bronchial artery intervention and intravenous chemotherapy is related to the types of lung cancer. According to the characteristics of lung cancer, it is believed that bronchial artery intervention is an important method of advanced lung cancer. Bronchial artery chemotherapy and embolization should be preferred if no embolism contraindication.