甲状腺乳头状癌术后刺激状态Tg与颈部淋巴结转移关系的研究

The correlation between the stimulated thyroglobulin level after surgery in papillary thyroid carci- noma and cervical lymph node metastasis

目的探讨甲状腺乳头状癌（PTC）患者术后刺激状态甲状腺球蛋白（Vg）与颈部淋巴结转移的关系。方法45例PTC患者行甲状腺全切或近全切并行颈部淋巴结清扫术，根据是否存在淋巴结转移分为L1和L02组，检测术后刺激状态Tg水平，采用统计学软件对数据进行t检验及相关性分析。结果2组患者的年龄（t=-0．675，P〉0．05）、性别（X^2=1．20，P〉0．05）差异无统计学意义，术后刺激状态Tg水平差异有统计学意义（t=4．167，P〈0．01）。L1组术后刺激状态Tg水平与颈部淋巴结转移水平呈正相关（r=0．676，P〈0．01）。结论PTC患者术后刺激状态Tg水平与颈部淋巴结转移关系密切，是评价PTC术后13^I治疗疗效及判断预后的重要指标。

Objective To discuss the correlation between the stimulated thyroglobulin （Tg） level after surgery in papillary thyroid carcinoma （PTC） and cervical lymph node metastasis. Methods Total thyroidectomy or subtotal thyroidectomy and radical cervical lymphadenectomy have been performed in 45 cases with PTC. All patients have been divided into two groups （L1 group and L0 group） according to whether lymph node metastasis exists. The stimulated Tg level after surgery were mesured and analyzed by t test with statistical software. Results There was no significant difference between the two groups in age （t=-0.675, P〉0.05 ） and gender 0（2= 1.20, P〉0.05 ）, but significant difference could be found in stimulated Tg level after surgery between the two groups （t=4.167, P〈0.01 ）. There was positive correlation between the stimu- latied Tg level after surgery and cervical lymph node metastasis in Ll group （r=0.676, P〈0.01 ）. Conclusion The stimulated Tg level after surgery is closely correlated to cervical lymph node metastasis in patients with PTC, which can be used as an assessment of the effect of the postsurgica113^I therapy and prognosis.